Enteric Fever — Tools for Prevention

This editorial examines global challenges in controlling typhoid and paratyphoid fever, highlighting insights from a large surveillance study in India. It discusses epidemiology, diagnostic limitations, and vaccine efficacy especially typhoid conjugate vaccines, which showed high effectiveness (>95%) against drug-resistant strains in Pakistan. The article also reviews alternative surveillance methods like serology and environmental sampling, and calls for broader vaccine deployment and accelerated development of paratyphoid vaccines. It emphasizes how enteric fever persists in low-resource settings due to inadequate sanitation and rising antimicrobial resistance.

This editorial examines global challenges in controlling typhoid and paratyphoid fever, highlighting insights from a large surveillance study in India. It discusses epidemiology, diagnostic limitations, and vaccine efficacy especially typhoid conjugate vaccines, which showed high effectiveness (>95%) against drug-resistant strains in Pakistan. The article also reviews alternative surveillance methods like serology and environmental sampling, and calls for broader vaccine deployment and accelerated development of paratyphoid vaccines. It emphasizes how enteric fever persists in low-resource settings due to inadequate sanitation and rising antimicrobial resistance.