Spermatogonium-Derived Complete Hydatidiform Mole

This brief report describes a rare case of a complete hydatidiform mole (CHM) derived from a spermatogonium, rather than a round spermatid, during assisted reproductive technology. The CHM was genetically identical to the paternal somatic cells and lacked maternally derived nuclear DNA. The patient, a 29-year-old woman with a history of azoospermia in her husband, underwent intrauterine implantation of a blastocyst obtained through round spermatid injection. The CHM developed into gestational trophoblastic neoplasia but resolved after chemotherapy. Genetic and epigenetic analyses confirmed the paternal origin of the CHM, highlighting the risks of unintentional spermatogonium injection in fertility treatments.

This brief report describes a rare case of a complete hydatidiform mole (CHM) derived from a spermatogonium, rather than a round spermatid, during assisted reproductive technology. The CHM was genetically identical to the paternal somatic cells and lacked maternally derived nuclear DNA. The patient, a 29-year-old woman with a history of azoospermia in her husband, underwent intrauterine implantation of a blastocyst obtained through round spermatid injection. The CHM developed into gestational trophoblastic neoplasia but resolved after chemotherapy. Genetic and epigenetic analyses confirmed the paternal origin of the CHM, highlighting the risks of unintentional spermatogonium injection in fertility treatments.