Arrhythmogenic Right Ventricular Cardiomyopathy

A 59-year-old woman with a family history of sudden cardiac death presented with syncope and subdural hematoma. During hospitalization, she developed sustained monomorphic ventricular tachycardia. Electrocardiogram revealed an incomplete right bundle-branch block, T-wave inversions (V1–V4), and an epsilon wave (V1). Imaging confirmed severe right ventricular dilation (ejection fraction: 27%) and regional akinesis, leading to a diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). Treatment included an implantable cardioverter defibrillator, metoprolol, and antiarrhythmic therapy. Follow-up showed biventricular heart failure (LVEF: 40%), prompting evaluation for cardiac transplantation. Genetic testing was negative for known pathogenic variants.

A 59-year-old woman with a family history of sudden cardiac death presented with syncope and subdural hematoma. During hospitalization, she developed sustained monomorphic ventricular tachycardia. Electrocardiogram revealed an incomplete right bundle-branch block, T-wave inversions (V1–V4), and an epsilon wave (V1). Imaging confirmed severe right ventricular dilation (ejection fraction: 27%) and regional akinesis, leading to a diagnosis of arrhythmogenic right ventricular cardiomyopathy (ARVC). Treatment included an implantable cardioverter defibrillator, metoprolol, and antiarrhythmic therapy. Follow-up showed biventricular heart failure (LVEF: 40%), prompting evaluation for cardiac transplantation. Genetic testing was negative for known pathogenic variants.