Glycogenic Hepatopathy

This case report describes an 18year old male with poorly controlled type 1 diabetes (glycated hemoglobin: 69 mmol/mol) who presented with diabetic ketoacidosis and markedly elevated aminotransferase levels (ALT: 972 U/L, AST: 300 U/L). Abdominal CT revealed hepatomegaly without parenchymal abnormalities. Liver biopsy confirmed glycogenic hepatopathy, characterized by glycogen laden hepatocytes on periodic acid Schiff staining and diastase sensitive deposits, excluding steatosis or hepatitis. The condition resolved with insulin therapy, normalizing liver enzymes within 3 weeks. Glycogenic hepatopathy, a reversible complication of uncontrolled diabetes, underscores the importance of metabolic management in preventing hepatic complications.

This case report describes an 18year old male with poorly controlled type 1 diabetes (glycated hemoglobin: 69 mmol/mol) who presented with diabetic ketoacidosis and markedly elevated aminotransferase levels (ALT: 972 U/L, AST: 300 U/L). Abdominal CT revealed hepatomegaly without parenchymal abnormalities. Liver biopsy confirmed glycogenic hepatopathy, characterized by glycogen laden hepatocytes on periodic acid Schiff staining and diastase sensitive deposits, excluding steatosis or hepatitis. The condition resolved with insulin therapy, normalizing liver enzymes within 3 weeks. Glycogenic hepatopathy, a reversible complication of uncontrolled diabetes, underscores the importance of metabolic management in preventing hepatic complications.