Case Series of Patients with Marburg Virus Disease, Equatorial Guinea, 2023

Candida auris, first identified in 2009 in Japan, has rapidly emerged as a global public health threat, now spanning more than 45 countries. Notably resistant to multiple antifungal classes and adept at colonizing human skin and hospital surfaces, C. auris frequently triggers outbreaks in healthcare settings. Whole-genome sequencing identifies five geographic clades with distinct drug resistance profiles and virulence traits. The organism evades innate immunity, persists in environmental reservoirs, and resists disinfection. Diagnostic advances including chromogenic media and qPCR and updated surveillance are vital. Treatment relies on echinocandins, though resistance is rising. The review emphasizes infection control, global surveillance, and new antifungal strategies to contain C. auris.

Candida auris, first identified in 2009 in Japan, has rapidly emerged as a global public health threat, now spanning more than 45 countries. Notably resistant to multiple antifungal classes and adept at colonizing human skin and hospital surfaces, C. auris frequently triggers outbreaks in healthcare settings. Whole-genome sequencing identifies five geographic clades with distinct drug resistance profiles and virulence traits. The organism evades innate immunity, persists in environmental reservoirs, and resists disinfection. Diagnostic advances including chromogenic media and qPCR and updated surveillance are vital. Treatment relies on echinocandins, though resistance is rising. The review emphasizes infection control, global surveillance, and new antifungal strategies to contain C. auris.