Fractional Flow Reserve or Intravascular Ultrasonography to Guide PCI

In patients with coronary artery disease evaluated for percutaneous coronary intervention (PCI), fractional flow reserve (FFR) and intravascular ultrasonography (IVUS) are used to guide revascularization and stent implantation. This study compared FFR-guided and IVUS-guided strategies in 1682 patients with intermediate stenosis (40–70% occlusion). The primary outcome was a composite of death, myocardial infarction, or revascularization at 24 months. Results showed FFR guidance was noninferior to IVUS guidance (8.1% vs. 8.5% event rate, respectively), with fewer stents implanted in the FFR group. Patient-reported outcomes were similar between groups.

In patients with coronary artery disease evaluated for percutaneous coronary intervention (PCI), fractional flow reserve (FFR) and intravascular ultrasonography (IVUS) are used to guide revascularization and stent implantation. This study compared FFR-guided and IVUS-guided strategies in 1682 patients with intermediate stenosis (40–70% occlusion). The primary outcome was a composite of death, myocardial infarction, or revascularization at 24 months. Results showed FFR guidance was noninferior to IVUS guidance (8.1% vs. 8.5% event rate, respectively), with fewer stents implanted in the FFR group. Patient-reported outcomes were similar between groups.