Stomaching Drug Delivery

This article discusses innovative approaches to overcoming the challenges of oral delivery for macromolecular drugs, such as peptides and proteins, which are often unstable or poorly absorbed in the gastrointestinal tract. The authors highlight a prototype gastric device called the self orienting millimeter scale applicator (SOMA), inspired by bioengineering principles. The SOMA uses a spring loaded mechanism to deliver drugs (e.g., insulin) directly into the gastric mucosa, bypassing traditional absorption barriers. Preclinical studies in pigs demonstrated successful systemic delivery of insulin, with transient hypoglycemia and no adverse effects. While promising, further research is needed to optimize device scalability, safety, and performance in human trials. The study represents a significant advancement in drug-device combinations for oral macromolecule delivery.

This article discusses innovative approaches to overcoming the challenges of oral delivery for macromolecular drugs, such as peptides and proteins, which are often unstable or poorly absorbed in the gastrointestinal tract. The authors highlight a prototype gastric device called the self orienting millimeter scale applicator (SOMA), inspired by bioengineering principles. The SOMA uses a spring loaded mechanism to deliver drugs (e.g., insulin) directly into the gastric mucosa, bypassing traditional absorption barriers. Preclinical studies in pigs demonstrated successful systemic delivery of insulin, with transient hypoglycemia and no adverse effects. While promising, further research is needed to optimize device scalability, safety, and performance in human trials. The study represents a significant advancement in drug-device combinations for oral macromolecule delivery.