Association between Angiotensin Blockade and Incidence of Influenza in the United Kingdom

This study analyzed UK electronic health records (1998–2016) to assess the impact of ACE inhibitors and ARBs on influenza incidence. Among 5.6 million individuals, ACE inhibitor use was associated with a lower risk of influenza (adjusted HR 0.66, 95% CI 0.62–0.70), with stronger effects observed with longer duration of use. ARBs showed similar trends. Findings suggest RAAS-blocking drugs may modulate susceptibility to viral respiratory infections like influenza and coronaviruses.

This study analyzed UK electronic health records (1998–2016) to assess the impact of ACE inhibitors and ARBs on influenza incidence. Among 5.6 million individuals, ACE inhibitor use was associated with a lower risk of influenza (adjusted HR 0.66, 95% CI 0.62–0.70), with stronger effects observed with longer duration of use. ARBs showed similar trends. Findings suggest RAAS-blocking drugs may modulate susceptibility to viral respiratory infections like influenza and coronaviruses.