Modeling Human Cardiac Chambers with Organoids

This article explores the development and potential applications of human cardiac organoids ("cardioids") for studying congenital heart defects and cardiac morphogenesis. Derived from pluripotent stem cells, these 3D structures mimic early heart development, featuring myocardial, endothelial, and epicardial cell layers. The study highlights breakthroughs in modeling cavitation (a key step in chamber formation) and endocardial-myocardial interactions, offering insights into conditions like hypoplastic left heart syndrome. The cardioid system also demonstrates utility in simulating injury responses, such as fibroblast migration and extracellular matrix deposition post cryoinjury. While current models are limited to primitive left ventricular like chambers, they provide a foundational platform for investigating congenital defects and testing regenerative therapies. The self-organizing nature of organoids underscores their promise for advancing understanding of human cardiogenesis and disease mechanisms.

This article explores the development and potential applications of human cardiac organoids ("cardioids") for studying congenital heart defects and cardiac morphogenesis. Derived from pluripotent stem cells, these 3D structures mimic early heart development, featuring myocardial, endothelial, and epicardial cell layers. The study highlights breakthroughs in modeling cavitation (a key step in chamber formation) and endocardial-myocardial interactions, offering insights into conditions like hypoplastic left heart syndrome. The cardioid system also demonstrates utility in simulating injury responses, such as fibroblast migration and extracellular matrix deposition post cryoinjury. While current models are limited to primitive left ventricular like chambers, they provide a foundational platform for investigating congenital defects and testing regenerative therapies. The self-organizing nature of organoids underscores their promise for advancing understanding of human cardiogenesis and disease mechanisms.