Thyroid Dermopathy in Graves’ Disease

A 49-year-old woman with a history of Graves’ disease presented with violaceous, nonpitting, indurated nodules on her arms and legs, alongside symptoms of thyrotoxicosis. Clinical examination revealed a goiter, proptosis, and lid lag. Laboratory tests confirmed hyperthyroidism with positive thyrotropin receptor and anti thyroid peroxidase antibodies. A skin biopsy demonstrated mucin deposition, confirming thyroid dermopathy, a condition caused by glycosaminoglycan accumulation in the dermis. Treatment included total thyroidectomy followed by levothyroxine therapy and topical glucocorticoids for the skin lesions, leading to symptom resolution. This case highlights the classic presentation and management of thyroid dermopathy, a rare extrathyroidal manifestation of Graves’ disease.

A 49-year-old woman with a history of Graves’ disease presented with violaceous, nonpitting, indurated nodules on her arms and legs, alongside symptoms of thyrotoxicosis. Clinical examination revealed a goiter, proptosis, and lid lag. Laboratory tests confirmed hyperthyroidism with positive thyrotropin receptor and anti thyroid peroxidase antibodies. A skin biopsy demonstrated mucin deposition, confirming thyroid dermopathy, a condition caused by glycosaminoglycan accumulation in the dermis. Treatment included total thyroidectomy followed by levothyroxine therapy and topical glucocorticoids for the skin lesions, leading to symptom resolution. This case highlights the classic presentation and management of thyroid dermopathy, a rare extrathyroidal manifestation of Graves’ disease.