Secondary Mitral Regurgitation

Mitral regurgitation arises from anatomical or functional impairment of the mitral apparatus. It is broadly classified into primary and secondary (or functional) mitral regurgitation, with the latter being a disease of the left ventricle or left atrium. In the United States, it is a common cause of moderate-to-severe valvular heart disease in adults over 55, with 65% of cases classified as secondary. Secondary mitral regurgitation results from abnormal left ventricular size, shape, or function. Guideline-directed medical therapy is the first-line approach for patients with heart failure and reduced left ventricular ejection fraction. Surgical or transcatheter interventions are considered only after maximal medical therapy has been administered without adverse effects

Mitral regurgitation arises from anatomical or functional impairment of the mitral apparatus. It is broadly classified into primary and secondary (or functional) mitral regurgitation, with the latter being a disease of the left ventricle or left atrium. In the United States, it is a common cause of moderate-to-severe valvular heart disease in adults over 55, with 65% of cases classified as secondary. Secondary mitral regurgitation results from abnormal left ventricular size, shape, or function. Guideline-directed medical therapy is the first-line approach for patients with heart failure and reduced left ventricular ejection fraction. Surgical or transcatheter interventions are considered only after maximal medical therapy has been administered without adverse effects