Secondary Hypertrophic Osteoarthropathy

This clinical case describes a 55-year-old woman with chronic joint pain and digital clubbing, ultimately diagnosed with secondary hypertrophic osteoarthropathy due to non small cell lung cancer. Radiographic imaging revealed symmetric periostitis of tubular bones, and a chest radiograph identified a large anterior mediastinal mass. Biopsy confirmed poorly differentiated non small cell carcinoma. Despite initiation of systemic chemotherapy, the patient succumbed to pneumonia two months later. The case highlights the diagnostic significance of clubbing and periostitis in identifying paraneoplastic syndromes.

This clinical case describes a 55-year-old woman with chronic joint pain and digital clubbing, ultimately diagnosed with secondary hypertrophic osteoarthropathy due to non small cell lung cancer. Radiographic imaging revealed symmetric periostitis of tubular bones, and a chest radiograph identified a large anterior mediastinal mass. Biopsy confirmed poorly differentiated non small cell carcinoma. Despite initiation of systemic chemotherapy, the patient succumbed to pneumonia two months later. The case highlights the diagnostic significance of clubbing and periostitis in identifying paraneoplastic syndromes.