Live Birth with or without Preimplantation Genetic Testing for Aneuploidy

This multicenter, randomized, controlled trial compared the cumulative live Birth rate between subfertile women undergoing preimplantation genetic testing for aneuploidy (PGT-A) and those undergoing conventional in vitro fertilization (IVF). The study included 1212 women aged 20–37 years with three or more good-quality blastocysts. Results showed that conventional IVF resulted in a noninferior cumulative live-birth rate (81.8%) compared to PGT-A (77.2%), with an absolute difference of 4.6 percentage points (95% CI, −9.2 to −0.0; P<0.001). The frequency of clinical pregnancy loss was lower in the PGT-A group (8.7% vs. 12.6%), but obstetrical and neonatal outcomes were similar between groups. The findings suggest that conventional IVF is noninferior to PGT-A for women with a good prognosis for live birth.

This multicenter, randomized, controlled trial compared the cumulative live Birth rate between subfertile women undergoing preimplantation genetic testing for aneuploidy (PGT-A) and those undergoing conventional in vitro fertilization (IVF). The study included 1212 women aged 20–37 years with three or more good-quality blastocysts. Results showed that conventional IVF resulted in a noninferior cumulative live-birth rate (81.8%) compared to PGT-A (77.2%), with an absolute difference of 4.6 percentage points (95% CI, −9.2 to −0.0; P<0.001). The frequency of clinical pregnancy loss was lower in the PGT-A group (8.7% vs. 12.6%), but obstetrical and neonatal outcomes were similar between groups. The findings suggest that conventional IVF is noninferior to PGT-A for women with a good prognosis for live birth.