Immune and Genome Engineering as the Future of Transplantable Tissue

This review explores the convergence of immune and genome engineering in advancing transplantable tissue and organ therapies. It discusses traditional regenerative medicine approaches, such as biomaterial scaffolds and stem cells, alongside emerging strategies like regenerative immunology and xenotransplantation. The article highlights the role of immune modulation (e.g., regulatory T cells) and genome editing (e.g., CRISPR-Cas9) in overcoming challenges like rejection and scaling. Innovations such as acellular extracellular matrices, interspecies chimeras ("exogenesis"), and transgenic pigs are examined as potential solutions to organ shortages and immune compatibility.

This review explores the convergence of immune and genome engineering in advancing transplantable tissue and organ therapies. It discusses traditional regenerative medicine approaches, such as biomaterial scaffolds and stem cells, alongside emerging strategies like regenerative immunology and xenotransplantation. The article highlights the role of immune modulation (e.g., regulatory T cells) and genome editing (e.g., CRISPR-Cas9) in overcoming challenges like rejection and scaling. Innovations such as acellular extracellular matrices, interspecies chimeras ("exogenesis"), and transgenic pigs are examined as potential solutions to organ shortages and immune compatibility.