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This first in human phase 1 study evaluated CARv3 TEAM E T cells engineered to …
This perspective article explores how medically tailored meals can mitigate the health impacts of food …
his letter reports extended efficacy data from the phase 3 RENOIR trial evaluating the bivalent …
A 38-year-old man with a history of kidney transplantation presented with a 2-week history of …
This phase 3a, double-blind, randomized, placebo-controlled trial evaluated the efficacy and safety of once-weekly cagrilintide …
This correspondence highlights how selpercatinib, a RET kinase inhibitor used in RET altered lung and …
This editorial discusses the evolving surgical standards in gynecologic oncology, particularly the shift from radical …
This correspondence evaluates the offtarget editing risk of exagamglogene autotemcel (exa cel), a CRISPR Cas9 …
This correspondence details a case study of a 29 year old man with WHIM like …
This phase 3 study evaluated exagamglogene autotemcel (exa-cel), a CRISPR Cas9 gene edited autologous cell …
This 52 week randomized, controlled trial evaluated the safety and efficacy of bempedoic acid in …
This phase 1 study evaluates NTLA 2002, a CRISPR Cas9 based in vivo gene-editing therapy …
A 57 year old woman with a history of depression and insomnia presented with severe …
This editorial reviews recent evidence on the management of subclinical atrial fibrillation (SCAF), particularly in …
A preterm male infant born at 31 weeks’ gestation via cesarean section for fetal distress …
This correspondence reports a case of long term HIV1 remission in a 63 year old …
This editorial discusses the landmark EV 302 phase 3 trial comparing enfortumab vedotin plus pembrolizumab …
This case details a 22-year-old woman transferred for acute headache, fever, respiratory failure, and …
This phase 3 trial (KEYNOTE-564) evaluated adjuvant pembrolizumab versus placebo in patients with clear cell …
Cardiovascular diseases remain the leading cause of global mortality, with over 19.8 million deaths in …
This Perspective argues for expanded and coordinated global regulatory capacity to ensure equitable access …
This phase 3 global trial evaluated adjuvant alectinib versus platinum based chemotherapy in patients with …
This Sounding Board article presents the 2024 National Academies of Sciences, Engineering, and Medicine (NASEM) …
This editorial discusses the ALINA phase 3 trial, which evaluated adjuvant alectinib therapy in patients …
This prospective, multicenter, matched case-control study assessed the real-world effectiveness of nirsevimab. a long-acting monoclonal …
This randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of a 6-month levofloxacin regimen …
Poor nutrition is a leading cause of illness and mortality, contributing to preventable diseases such …
This editorial discusses the emerging role of levofloxacin as preventive therapy for individuals exposed …
This clinical image report describes a 20-year-old woman who presented with headache, diplopia, and right …
This double-blind, controlled clinical trial evaluated the safety and efficacy of immunization with a …
This Perspective examines the evolving crisis of medical expertise and trust in the U.S., especially …
This phase 3a trial evaluated the efficacy and safety of coadministered cagrilintide and semaglutide (CagriSema) …
This phase 3 study evaluated exagamglogene autotemcel (exa-cel), a CRISPR Cas9 gene edited autologous cell …
A 32-year-old man with well-controlled HIV presented with a 1-month history of painful forehead nodules. …
This editorial evaluates the findings of the VITAL trial, a large scale randomized study testing vitamin …
This randomized trial conducted in Kenya tested whether fractional doses (20% and 40%) of 10-valent …
A 76 year old man presented with sudden-onset blood-filled blisters on the tongue, without prior …
This cluster-randomized trial assessed whether a reduced schedule of the 10-valent pneumococcal conjugate vaccine (PCV10) …
A 70-year-old woman presented with persistent right upper quadrant abdominal pain and systemic symptoms including …
This article chronicles the scientific and clinical breakthroughs behind GLP1 based drugs, which have transformed …
This letter outlines unusual clinical and laboratory features of HIV infection during long-acting cabotegravir …
This Perspective outlines the clinical, epidemiologic, and public health implications of mpox (monkeypox virus, MPXV) …
This editorial explores the progress and challenges in preventing type 1 diabetes mellitus (T1DM), an …
This clinical decision article examines whether to initiate levothyroxine treatment in a 31 year old …
This editorial reflects on the historical, ethical, and clinical evolution of HIV-positive organ donation, culminating …
This study evaluates the efficacy of ring vaccination using the rVSV-ZEBOV-GP vaccine during the 2018–2020 …
This Perspective advocates for a whole-system approach to combating antimicrobial resistance (AMR), emphasizing the …
This case chronicles the diagnostic journey of an 8-year-old girl with prolonged fever, pharyngitis, and …
Candida auris, first identified in 2009 in Japan, has rapidly emerged as a global public …
A 58-year-old man with prior splenectomy presented with 3 weeks of fatigue, fever, anorexia, headache, …
This Perspective critiques the U.S. government's early response to emerging H5N1 influenza outbreaks in farm …
This interactive case discussion evaluates whether empirical antibiotics or chest radiography should guide treatment for …
This brief report describes a 58 year old woman with severe ankylosing spondylitis and consanguineous …
This case profiles a 56-year-old woman with end-stage liver disease secondary to metabolic dysfunction-associated steatohepatitis, …
A 24-year-old man was admitted in March 1923 with acute fever, pleuritic chest pain, chills, …
This multicenter, observational, noninferiority study evaluated the safety of kidney transplantation from deceased donors with …
This article discusses innovative approaches to overcoming the challenges of oral delivery for macromolecular drugs, …
This clinical decision article explores the debate over intravenous fluid choice for resuscitation in diabetic …
In June 2019, a tick-bitten patient in Inner Mongolia presented with fever and multiorgan dysfunction, …
This editorial summarizes an NEJM audio interview recorded on February 6, 2023, featuring Drs. Eric …
This randomized, open-label study evaluated the effectiveness of doxycycline postexposure prophylaxis (DoxyPEP) in reducing bacterial …
This phase 2–3 double-blind, placebo-controlled trial evaluated the efficacy and safety of oral nirmatrelvir–ritonavir as …
This correspondence describes a stillbirth associated with vertical transmission of Oropouche virus (OROV) in a …
This firsthand account documents the clinical and ethical decision-making of a critical care physician during …
This article traces the decades-long evolution of vaccine development for respiratory syncytial virus (RSV), highlighting …
This editorial discusses the TRUNCATE-TB trial, which tested a strategic approach to shortening treatment …
This original article presents results from two phase 2a randomized controlled trials evaluating the safety …
A healthy 2-year-old presented with a 4-week history of painless alopecia and black dots on …
This review examines the profound global health impacts of food and nutrition insecurity, affecting 2.33 …
This editorial discusses the advancements in automated insulin delivery systems for patients with type 1 …
This correspondence describes a California-wide collaboration to monitor mpox (formerly monkeypox) outbreaks via wastewater-based surveillance. …
This large cluster-randomized trial (AVENIR) in Niger evaluated the mortality impact of twice-yearly azithromycin distributions …
Periprosthetic joint infection (PJI) is a biofilm-driven, prosthesis-specific condition distinct from native bone infection. Symptoms …
This Clinical Decisions piece presents a vignette of a 72-year-old woman with quadriplegia, neurogenic bladder, …
This serologic study evaluates live-virus neutralization of emergent SARS-CoV-2 omicron subvariants (BA.2.75.2, BQ.1.1, and XBB) …
This study assessed the neutralization resistance of SARS-CoV-2 Omicron subvariants BQ.1.1 and XBB.1, which harbor …
This case concerns a previously healthy 47-year-old man with acute onset of confusion, myalgias, and …
This clinical image report describes a 25-year-old woman with systemic lupus erythematosus (SLE) who presented …
A 29-year-old man with HIV presented with a 2-week history of left-sided abdominal pain. …
This Perspective from CMS leaders discusses the alignment of quality measures across federal programs through …
This perspective discusses the absence of reliable, nationwide public health data during the Covid-19 pandemic …
This correspondence reports on the neutralization capacity of ZF2001 (homotypic RBD-dimer vaccine), inactivated-virus vaccines, …
This clinical letter compares neutralizing antibody responses in adults ≥55 years after receiving a fourth …
This randomized, open-label, noninferiority trial evaluates whether a treatment strategy using an initial 8-week …
This correspondence presents results from an extension of a phase 2 randomized trial evaluating the …
This multi-article Perspective series showcases innovative responses to inequity in U.S. health care delivery. Initiatives …
This Perspective explores the precarious legal and operational status of health care in U.S. correctional …
This international phase 3 trial evaluated the efficacy and safety of a single dose of …
This Images in Clinical Medicine report documents a case of cerebral cystic echinococcosis in a …
This Perspective article explores the complexities and missteps in global polio eradication efforts, particularly in …
This article examines the growing threats to the authority and regulatory power of medical licensing …
This phase 3, randomized, placebo-controlled trial evaluates the efficacy of a single dose of pegylated …
This editorial summarizes an NEJM audio interview recorded on January 17, 2023, featuring Drs. Eric …
This article explores the role of biomechanical forces in determining the fate of pancreatic progenitor …
A 70-year-old kidney transplant recipient with a complex medical history including ANCA-associated vasculitis, coronary artery …
A 76-year-old man presented with exertional dyspnea and fatigue, progressing over one month. Despite normal …
A 32-year-old man presented with necrotic chest wounds following daily injection of fentanyl adulterated with …
This perspective by Paul A. Offit critically examines the development and deployment of bivalent mRNA …
This multimedia Perspective includes a short narrative titled Venkamma's Dowry and an accompanying “Double Take” …
A previously healthy 54-year-old man presented with bloody diarrhea and cutaneous lesions. Examination revealed signs …
This letter evaluates the comparative risks of four cardiovascular events ischemic stroke, hemorrhagic stroke, myocardial …
This study investigated rising resistance to artemisinin in Plasmodium falciparum and increasing prevalence of HRP2-negative …
This Editorial accompanies an audio interview with NEJM editors Eric J. Rubin, Lindsey R. Baden, …
A 78-year-old man with diabetes and COPD presented with a 2-month history of dysphonia while …
This correspondence reports on a case series of 55 hemodialysis patients who had received …
This Perspective highlights the ongoing challenges in identifying and treating long Covid, or postacute sequelae …
This editorial examines conflicting trial results on the efficacy of adjunct glucocorticoid therapy for severe …
This case concerns a 30-year-old woman, six days postpartum, presenting with fever, abdominal pain, and …
This international study assessed 2017 children hospitalized with SARS-CoV-2 infection and diagnosed with multisystem inflammatory …
This nationwide matched case-control study evaluated the effectiveness of the four-component meningococcal group B vaccine …
This editorial captures reflections from three editors of the New England Journal of Medicine Eric …
This brief case report presents a 29-year-old man with tuberculous optochiasmatic arachnoiditis, a rare complication …
This perspective article evaluates 20 years of impact from the U.S. President’s Emergency Plan for …
This “Images in Clinical Medicine” case highlights a 24-year-old kidney transplant recipient presenting with acute …
This correspondence analyzes the real-world effectiveness of prior SARS-CoV-2 infections in preventing reinfection with the …
This review article examines Hepatitis D Virus (HDV), a defective viral pathogen dependent on …
This article advocates for targeted masking policies in health care settings beyond the SARS-CoV-2 emergency …
A 39-year-old man with HIV on antiretroviral therapy presented with a year-long history of recurrent, …
This correspondence presents evidence that real-time quaking-induced conversion (RT-QuIC) assays can detect misfolded prion protein …
This editorial reviews two phase 3 trials evaluating the RSVpreF vaccine, a bivalent RSV fusion …
This letter to the editor describes a cluster of 21 mpox (MPXV) cases traced to …
This image-based case presents a previously healthy 26-year-old man with a 5-day history of malaise, …
This policy-oriented perspective outlines challenges and recommendations for global sharing of pathogen genomic sequence data. …
This editorial evaluates findings from the A-PLUS trial, a placebo-controlled, randomized study conducted in eight …
A 44-year-old man with HIV and intermittent antiretroviral adherence presented with a month-long history of …
This phase 3 trial evaluated a bivalent RSV prefusion F protein-based vaccine (RSVpreF) in adults …
This perspective outlines the evolution of wastewater surveillance from a pandemic-era innovation into a foundational …
This Correspondence presents six cases of autochthonous leprosy locally acquired leprosy diagnosed in U.S.-born …
A 38-year-old man presented with a 9-month history of mildly itchy groin rash misdiagnosed as …
This editorial discusses the persistent global challenge of meningococcal disease, emphasizing its epidemic impact in …
This Perspective analyzes the contentious debate surrounding SARS-CoV-2's origins, outlining both the zoonotic spillover hypothesis …
This Perspective article discusses the ethical, legal, and clinical implications of approving workplace accommodations …
This editorial summarizes an audio interview conducted on March 27, 2023, featuring editors of The …
This correspondence reanalyzes data from a randomized trial comparing subcutaneous versus intradermal administration of the …
A 58-year-old woman was evaluated at Massachusetts General Hospital for fatigue, abdominal bloating, and eosinophilia …
This editorial highlights a conversation between NEJM editors and Dr. Anthony Fauci, recorded on …
This editorial discusses two randomized controlled trials (PERL and CKD-FIX) investigating the efficacy of urate-lowering …
This correspondence in The New England Journal of Medicine documents cases of multisystem inflammatory syndrome …
This Correspondence reports a novel anti–platelet factor 4 (PF4) disorder resembling vaccine-induced immune thrombotic thrombocytopenia …
This perspective critiques the U.S. Supreme Court’s 2025 decision in United States v. Skrmetti, which upheld …
This international randomized platform trial (REMAP-CAP) evaluated simvastatin (80 mg daily) in critically ill Covid-19 …
In autumn 2022, an unusually early surge in respiratory syncytial virus (RSV) infections was …
This comprehensive review outlines the evolution, challenges, and advancements in liver transplantation. It emphasizes global …
This perspective article warns of yellow fever’s potential resurgence in the U.S. South due to …
This editorial highlights the interim results of the phase 3 ESSENCE trial, demonstrating semaglutide’s efficacy …
This perspective piece outlines the critical threat facing the global fight against HIV/AIDS due to …
This perspective piece criticizes the Joint Commission’s decision to make hospital sustainability standards optional rather …
This correspondence details the death of a 33-year-old man in the United States who had …
This perspective article examines the growing complexity and widespread use of laboratory-developed tests (LDTs), emphasizing …
This case involves a 3-year-old girl who presented with dark urine and jaundice one week …
This Perspective article explores the underrecognized intersection between HIV/AIDS and mental health in Africa, where …
The ConquerRSV phase 2–3 trial evaluated the mRNA-1345 vaccine (Moderna) encoding the stabilized RSV prefusion …
This editorial examines global challenges in controlling typhoid and paratyphoid fever, highlighting insights from a …
This multicenter Chinese study evaluates anti-BNLF2b total antibody (P85-Ab) as a novel screening biomarker for …
This Clinical Practice review presents a comprehensive evaluation and treatment approach to community-acquired pneumonia (CAP), …
A 38-year-old man with a prior corneal transplant presented with symptoms including tearing and reduced …
This randomized, placebo-controlled trial evaluated inhaled fluticasone furoate (200 µg daily for 14 days) in …
This brief report describes three cases of melioidosis identified between 2020 and 2023 in residents …
This Original Article presents data from the NSSEFI study conducted from 2017 to 2020 across …
This randomized, double blind, placebo controlled trial (PIONEER 6) evaluated the cardiovascular safety of once …
This case report details a 37-year-old man presenting with a progressive, morbilliform rash affecting the …
This comprehensive review examines Shiga toxin–producing Escherichia coli (STEC) as major causes of bloody …
This case involves a 44-year-old man with diabetes mellitus and end-stage kidney disease, presenting with …
This multicenter, randomized, noninferiority trial compared two glucose threshold values for treating asymptomatic moderate hypoglycemia …
ATP citrate lyase (ACLY) is an enzyme in the cholesterol biosynthesis pathway upstream of HMGCR, …
This editorial reviews pivotal progress in RSV vaccine development, culminating in 2023 with approval of …
This NEJM editorial by Moskowitz and Gong reviews the implications of the REMAP-CAP trial simvastatin …
This review article explores the diverse mechanisms by which medications can adversely affect thyroid function …
Hypoparathyroidism is a rare disorder characterized by deficient parathyroid hormone (PTH) production, leading to hypocalcemia …
This letter from the NYC OSMI study reports immunogenicity outcomes following MVA-BN (JYNNEOS) mpox vaccination …
This NEJM Perspective outlines emerging threats to malaria control in sub-Saharan Africa, particularly artemisinin-resistant Plasmodium …
This phase 2 study evaluated the safety and efficacy of vosoritide, a C-type natriuretic peptide …
This case describes a 70-year-old woman from KwaZulu-Natal, South Africa with advanced HIV infection (CD4 …
This perspective piece explores the historical and cultural influence of gender norms on mask-wearing behavior …
This perspective details a multidisciplinary response to a Rift Valley fever (RVF) outbreak in Uganda, …
This NEJM Case Records report chronicles a diagnostic challenge involving a 38-year-old woman with progressive …
This editorial inaugurates NEJM’s new series on medical ethics, highlighting how advances in medicine continually …
This brief report describes the first clinical case of a gene edited porcine kidney xenotransplant …
This editorial discusses the findings of a study comparing 5year outcomes of gastric bypass surgery …
This article explores the molecular mechanisms by which mesenchymal stem cells (MSCs) differentiate into osteoblasts …
In a large multicenter randomized controlled trial, critically ill adults undergoing invasive mechanical ventilation for …
This personal perspective by Kaitlyn K. Rogers, a medical student with type 1 diabetes, explores …
This open-label, randomized trial (CONFIDENT trial) studied 475 mechanically ventilated adults with Covid-19–induced ARDS across …
Congenital adrenal hyperplasia (CAH) due to 21-hydroxylase deficiency is one of the most common autosomal …
The DECLARE TIMI 58 trial evaluated the cardiovascular safety and efficacy of dapagliflozin, an SGLT2 …
This editorial analyzes the HEART-FID trial evaluating intravenous ferric carboxymaltose in 3065 symptomatic ambulatory patients …
This editorial reviews the findings of the THEMIS trial, part of the PARTHENON clinical development …
Thyroid eye disease (TED) is a debilitating autoimmune condition with no FDA approved medical therapy. …
Two phase 3 trials (ORION 10 and ORION 11) evaluated the efficacy and safety of …
Mobile health (mHealth) leverages sensors, apps, and AI to monitor and manage wellness and disease, …
The SELECT trial, a randomized, placebo-controlled, event-driven superiority study evaluated whether once-weekly semaglutide 2.4 mg …
A 55 year old woman with chronic renal insufficiency presented with recurrent falls, dizziness, and …
This editorial examines the mechanisms behind improved insulin sensitivity and type 2 diabetes remission following …
This correspondence reports the successful use of the FGFR13 tyrosine kinase inhibitor infigratinib in a …
This perspective article examines the implications of Idaho’s Fairness in Women’s Sports Act, which bars transgender …
Tirzepatide, a dual GIP and GLP-1 receptor agonist, was compared with semaglutide, a GLP-1 receptor …
This correspondence describes a multidisciplinary approach to oocyte cryopreservation in a 16-year-old transgender male adolescent …
The MULTISTARS AMI trial randomized 840 hemodynamically stable patients with ST-segment elevation myocardial infarction (STEMI) …
This multicenter, double-blind, randomized RESCUE BT2 trial evaluated intravenous tirofiban versus oral aspirin in 1177 …
This NEJM editorial reviews the evolving management of aortic-valve stenosis, emphasizing two key decisions: when …
The DAPA HF trial evaluated the efficacy and safety of dapagliflozin, an SGLT2 inhibitor, in …
This phase 3 trial evaluated the efficacy and safety of once-weekly subcutaneous semaglutide (2.4 mg) …
This phase 2, randomized, placebo controlled trial evaluated the efficacy and safety of oveporexton (TAK-861), …
This comprehensive NEJM review describes the anatomy, pathophysiology, diagnosis, and treatment of right ventricular (RV) …
This NEJM editorial critiques the ECLS-SHOCK trial, which evaluated whether early use of extracorporeal life …
This editorial reflects on a decade of genomic screening through the lens of ACMG Secondary …
The OCTOBER trial, conducted across 38 European centers randomized 1201 patients with complex coronary-artery bifurcation …
This editorial discusses the global rise in overweight and obesity, focusing on China, where the …
This population-based analysis from the Global Cardiovascular Risk Consortium pooled individual-level data from 1,518,028 participants …
This phase 3, double blind, placebo controlled trial evaluated the efficacy and safety of once …
This Perspective article advocates for expanding Medicaid coverage of comprehensive obesity-management interventions. The authors critique …
This case describes a 36-year-old woman who developed swelling and bluish discoloration of her left …
This NEJM Perspective by Richard Waring recounts his experience as a patient with atrial flutter …
This NEJM editorial assesses global data on five key modifiable cardiometabolic risk factors elevated systolic …
The ADVENT trial was a multicenter, randomized, single-blind, noninferiority study comparing pulsed field ablation (PFA) …
This review article examines the health effects of milk and dairy consumption, addressing both potential …
This NEJM Perspective explores ethical, regulatory, and clinical implications of implanting implantable cardioverter-defibrillators (ICDs) subject …
Evidence of the effectiveness of obesity treatment in underserved primary care populations is limited. This …
This case report describes an 80 year old woman with a history of progressive forehead …
This Clinical Decisions feature presents a case of a 67-year-old man with hypertension, obesity, and …
The ECLS-SHOCK trial investigated whether early extracorporeal life support (ECLS) improves survival in patients with …
: This NEJM editorial reviews the evolving evidence around complete revascularization in patients with STEMI …
The FIRE trial a multicenter, randomized study compared physiology-guided complete revascularization versus culprit-lesion-only PCI in …
This phase 3 randomized trial (APOLLO-B) assessed patisiran—a lipid nanoparticle siRNA therapeutic—in 360 patients with …
This clinical case study describes a 44 year old man presenting with fatigue, weight loss, …
This NEJM editorial interprets the ILUMIEN IV and OCTOBER trials, which evaluated whether optical coherence …
This NEJM case details a 75-year-old man with atrial tachyarrhythmias, tricuspid regurgitation, and pericarditis …
This correspondence presents three rare cases of spontaneous regression in ATTR amyloidosis–associated cardiomyopathy (ATTR-CM), a …
This clinical case study presents a 63 year old woman with a history of atraumatic …
This multicenter randomized controlled trial (NCT04415658) evaluated intravenous levothyroxine (30 µg/hr for ≥12 hr) versus …
This editorial interprets the findings of the ORBITA-2 trial—a double-blind, placebo-controlled study showing that …
This editorial highlights the efficacy of selpercatinib, a highly selective RET inhibitor, in treating RET-altered …
This NEJM correspondence describes a prospective study of 50 patients with severe aortic stenosis and …
This NEJM editorial assesses the CASTLE-HTx trial, which examined catheter ablation for atrial fibrillation in …
This phase 2 trial evaluated the efficacy of golimumab, a TNF-α inhibitor, in preserving beta …
This NEJM editorial explores whether heart failure with preserved ejection fraction (HFpEF) is primarily a …
: This case report describes a 67-year-old woman with atrial fibrillation who was admitted for …
Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, was evaluated in patients with chronic kidney disease …
The HEART-FID trial was a randomized, double-blind study evaluating intravenous ferric carboxymaltose (FCM) versus placebo …
This NEJM brief report describes two Filipino siblings with cardiomyopathy, hypertension, arrhythmia, and isolated left …
This editorial discusses the challenges of defining clinical trial endpoints for metabolic dysfunction-associated steatohepatitis (MASH) …
A 69-year-old woman with a 3-year history of exertional dyspnea presented with signs of volume …
This phase 3, double blind, randomized trial evaluated the efficacy and safety of inclisiran, a …
This correspondence describes two patients, a 5-year-old boy and a 58-year-old woman who developed symptomatic …
This study compared the metabolic effects of Roux-en-Y gastric bypass surgery and diet therapy in …
This case report describes a 14-year-old boy who developed acute hypotension and right ventricular failure …
This editorial evaluates the FIRE trial, which randomized 1445 patients (≥75 years old; median age …
This multicenter, double blind trial evaluated the cardiovascular effects of ertugliflozin, an SGLT2 inhibitor, in …
The CASTLE-HTx trial evaluated catheter ablation plus medical therapy versus medical therapy alone in patients …
This NEJM editorial chronicles the invention, engineering foundation, and transformative clinical impact of optical coherence …
This multicenter, double-blind, randomized NOAH-AFNET 6 trial evaluated whether oral anticoagulation with edoxaban benefits patients …
A 21-year-old college student presented with progressive dyspnea, initially misdiagnosed as exercise-induced asthma. Diagnostic imaging …
This double blind, placebo controlled trial evaluated the cardiovascular efficacy of once daily oral semaglutide …
This editorial discusses the role of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in managing chronic …
Poor nutrition is a leading cause of preventable diseases, contributing to over half a million …
This large-scale population study assessed the prevalence and survival implications of actionable genotypes in 73 …
A 70 year old man with a history of hairy cell leukemia (in remission) and …
This editorial highlights the disparities in obesity management in primary care, particularly among socioeconomically disadvantaged …
This NEJM editorial evaluates the ADVENT trial, which compared pulsed field ablation (PFA) to conventional …
The ORBITA-2 trial, a double-blind, randomized, placebo-controlled study evaluated the effect of PCI versus placebo …
This editorial reviews the development and scientific impact of AlphaFold, the deep learning system created …
Malnutrition in older adults, defined as undernutrition (protein-energy malnutrition), is a prevalent condition with serious …
This case study presents a 61 year old man with undiagnosed pheochromocytoma who underwent elective …
This phase 1–2 trial evaluated the efficacy and safety of selpercatinib, a selective RET kinase …
The COACH trial a stepped-wedge, cluster-randomized study across 10 hospitals in Ontario, tested whether a …
This first-in-human phase 1 trial evaluated NI006, a recombinant human monoclonal antibody designed to selectively …
This editorial discusses the potential of automated insulin delivery (AID) systems for patients with type …
Aldosterone dysregulation contributes to hypertension. Lorundrostat, an aldosterone synthase inhibitor, was evaluated in a multicenter, …
This editorial contextualizes the RENOVATE-COMPLEX-PCI trial, which demonstrated improved outcomes in complex percutaneous coronary …
This study evaluated the long term effects of bariatric surgery on life expectancy in patients …
This multicenter, randomized, open label trial evaluated the efficacy and safety of a closed loop …
This editorial examines the current evidence and challenges surrounding extracorporeal CPR (ECPR) for out-of-hospital cardiac …
The Covid-19 pandemic has highlighted stark racial and ethnic disparities in infection rates, hospitalizations, and …
This NEJM editorial reviews the BeNeDuctus trial findings and challenges the practice of early pharmacologic …
This editorial evaluates 5-year results from the COAPT trial, which randomized 614 patients with heart …
This review explores the pivotal role of circadian rhythms in human physiology and disease, highlighting …
This editorial discusses the challenges in diabetes management, including inadequate glycemic control despite advancements in …
This study investigated the effects of intensive versus standard blood pressure control in patients with …
This international, randomized TRILUMINATE Pivotal trial evaluated transcatheter edge-to-edge repair (TEER) for symptomatic severe tricuspid …
This case report describes a 47 year old man with type 2 diabetes who developed …
A 33 year old woman with celiac disease presented with painless tongue discoloration lasting 3 …
This personal narrative recounts the author's childhood experience of being diagnosed with type 1 diabetes …
This 3-year follow-up of the EARLY-AF randomized trial evaluated whether initial rhythm-control therapy with cryoballoon …
This editorial examines the evolving evidence base for temperature management following out-of-hospital cardiac arrest, focusing …
This multicenter, randomized, controlled trial evaluated the efficacy and safety of automated insulin delivery (AID) …
This prospective, multicenter randomized trial (RENOVATE-COMPLEX-PCI) compared intravascular imaging–guided versus angiography-guided percutaneous coronary intervention …
A newborn girl presented with a large neck mass detected prenatally at 34 weeks of …
This Science Behind the Study editorial explores the rationale for targeting aldosterone synthesis in resistant …
This article reviews the benefits and risks of hormone therapy for postmenopausal women, focusing on …
This study analyzed the lifetime risk of cardiovascular disease (CVD) and death from any cause …
This image-based case report presents a 60-year-old man with exertional dyspnea and a history of …
This article explores the challenges and recent advances in beta cell replacement therapy for type …
This double-blind, phase 3 trial (STELLAR) evaluated sotatercept, a ligand trap targeting activins and growth …
This randomized, double-blind, placebo-controlled trial (EMPA-KIDNEY) evaluated empagliflozin in 6609 patients with chronic kidney disease …
In this phase 2b, randomized, placebo controlled trial, the efficacy and safety of efruxifermin, a …
This editorial discusses the clinical, ethical, and logistical considerations surrounding heart transplantation from donors after …
This editorial summarizes findings from the Vitamin D and Omega 3 Trial (VITAL) and its …
This case report describes a 50-year-old man with a history of mitral-valve prolapse and remote …
The DAPA CKD trial evaluated the efficacy and safety of dapagliflozin, an SGLT2 inhibitor, in …
This editorial evaluates cardiovascular disease (CVD) risk among people living with HIV, who face …
This editorial introduces transcatheter arterialization of deep veins, a novel approach for patients with no …
This editorial discusses the emerging role of bempedoic acid, a liver-specific ATP citrate lyase inhibitor …
This randomized, controlled trial (TAME) investigated whether mild hypercapnia (PaCO₂ 50–55 mm Hg) improves neurologic …
This phase 1 multicenter trial evaluated zilebesiran, a hepatocyte-targeted small interfering RNA (siRNA) therapeutic designed …
This multicenter, randomized, placebo-controlled phase 2 trial (BrigHTN) investigated the efficacy and safety of baxdrostat, …
A 25 year old man presented with sudden onset limb weakness, palpitations, and insomnia. Examination …
This clinical decision article discusses the management of an incidentally discovered retrievable inferior vena cava …
This multicenter, randomized noninferiority trial (BeNeDuctus) compared expectant management versus early ibuprofen treatment in 273 …
This clinical decision article explores the management of a 31-year-old woman with type 1 diabetes …
This study describes two cases of acquired parathyroid hormone (PTH) resistance due to autoantibodies targeting …
This randomized crossover trial examined the acute effects of caffeinated coffee on arrhythmias, physical activity, …
This perspective details the FDA’s 2020 decision to withdraw the weight-loss drug lorcaserin (Belviq) from …
This randomized, placebo-controlled trial evaluated bempedoic acid, a liver-activated ATP citrate lyase inhibitor for its …
This multicenter, randomized, noninferiority trial compared outcomes after heart transplantation using donor hearts retrieved following …
An 18-year-old woman presented with a 2-month history of headaches, midscapular pain, and oral ulcers, …
This randomized controlled trial (COAPT) evaluated long-term outcomes of transcatheter edge-to-edge repair (MitraClip) for patients …
This randomized controlled trial investigated whether 36 or 72 hours of device-based fever prevention …
This editorial discusses the limited reach of thrombolysis and thrombectomy in acute ischemic stroke treatment …
This multicenter, randomized noninferiority trial compared aspirin and low-molecular-weight heparin (LMWH) for thromboprophylaxis in 12,211 …
This perspective article reflects on the 100-year history of insulin since its discovery in 1921, …
This prospective, single-group, multicenter PROMISE II trial evaluated the safety and efficacy of transcatheter arterialization …
This article critiques the misuse of race in medical education, highlighting how preclinical curricula often …
This multicenter randomized controlled trial (INCEPTION), conducted in the Netherlands, assessed whether extracorporeal CPR (ECPR) …
This editorial discusses the evolution of diabetes technology, focusing on automated insulin-delivery systems (closed-loop systems) …
This phase 3, open label trial compared the efficacy and safety of once weekly tirzepatide …
This editorial discusses hospital-acquired venous thromboembolism (VTE) prevention in patients with traumatic limb and pelvic …
This case examines a 56-year-old man with a history of alcohol and opioid use who …
A 47-year-old woman with no prior medical history presented with shortness of breath and was …
This Clinical Problem-Solving case discusses a 68-year-old woman with progressive palpitations, dyspnea, and chest pressure, …
This double-blind trial evaluated the efficacy and safety of once-weekly subcutaneous semaglutide (2.4 mg) combined …
This editorial reviews the cardiovascular safety of testosterone-replacement therapy in older men, contextualized by results …
This large international study involving 137,851 participants from 20 countries examined the association between dietary …
A 27 year old pregnant woman presented with new-onset diabetes, hypertension, proximal muscle weakness, and …
This editorial discusses evidence from the EARLY-AF trial and its follow-up, comparing first-line cryoballoon ablation …
The phase 3 REPRIEVE trial evaluated pitavastatin for primary prevention of cardiovascular disease (CVD) in …
In patients with coronary artery disease evaluated for percutaneous coronary intervention (PCI), fractional flow reserve …
This double blind, placebo-controlled trial evaluated the cardiovascular effects of finerenone, a nonsteroidal mineralocorticoid receptor …
This editorial reviews the clinical dilemma of when to initiate anticoagulation for secondary stroke …
The first Perspective, “The Fresh Assault on Insurance Coverage Mandates”, analyzes legal and political …
A 54 year old man with stage 4 chronic kidney disease presented with confusion, vomiting, …
Obesity is strongly associated with increased susceptibility to various diseases, including certain cancers. This article …
The goal of gene therapy for patients with hemophilia A is to safely impart long-term …
A 32-year-old man from an area with high fluoride levels in groundwater presented with chronic …
his Perspective article outlines the growing demand for new-generation antiobesity medications like semaglutide and tirzepatide, …
A 78 year old man with type 2 diabetes presented with a 1 week history …
This editorial reviews the COACH trial, a stepped-wedge, cluster-randomized study involving over 5000 patients from …
his original research article evaluates the safety and performance of a dual-chamber leadless pacemaker system …
The Covid-19 pandemic exposed critical flaws in the U.S. health care system’s approach to chronic …
This randomized, placebo controlled trial evaluated the cardiovascular and renal effects of efpeglenatide, a weekly …
This study investigates the incidence and clinical outcomes of myocarditis following BNT162b2 mRNA COVID-19 vaccination …
This Clinical Problem-Solving case follows a 58-year-old woman whose constellation of symptoms pleuritic chest pain, …
This case involves a 53-year-old woman with celiac disease who developed progressive watery diarrhea that …
This editorial highlights the potential of dual incretin therapy (combining glucose dependent insulinotropic polypeptide [GIP] …
This phase 3 trial evaluated the efficacy and safety of daprodustat, an oral hypoxia-inducible factor …
This randomized open-label trial (ELAN) evaluated the safety and efficacy of early versus later …
This perspective article explores how economic principles can inform public health policy, particularly in addressing …
This Clinical Decisions feature presents the case of a 35-year-old man with intravenous heroin use …
An 82 year old man with diabetes, chronic pancreatitis, and biliary strictures presented with fever, …
This case report describes a 16 year old boy presenting with a 17 month history …
The FIGARO-DKD trial evaluated the cardiovascular effects of finerenone, a nonsteroidal mineralocorticoid receptor antagonist, in …
This editorial reviews major therapeutic advancements in pulmonary arterial hypertension (PAH), highlighting progress from early …
This editorial discusses the discovery of GNAS gene variants encoding the stimulatory G protein alpha subunit (Gαs) …
This perspective addresses the critical shortage of iodinated contrast material in the U.S. due to …
his case report describes a 75 year old man presenting with a 6-month history of …
This randomized, double-blind, placebo-controlled trial (TRAVERSE) assessed cardiovascular safety of testosterone-replacement therapy in 5246 men …
This review explores the convergence of immune and genome engineering in advancing transplantable tissue and …
Adrenal incidentalomas, detected incidentally during imaging for unrelated conditions, are found in 1–6% of adults, …
This multicenter, double blind trial evaluated the safety and efficacy of sotagliflozin, a dual SGLT1 …
The authors conducted a multicenter trial to compare immediate coronary angiography versus delayed/selective angiography in …
Obesity is a chronic disease with significant global morbidity and mortality. This phase 3 double …
Therapeutic-dose anticoagulation with heparin was evaluated in critically ill patients with Covid-19 to determine if …
This correspondence describes vaccine-induced thrombocytopenia (VIT) with severe headache as a potential precursor to vaccine-induced …
The STEP trial investigated the effects of intensive blood-pressure control (target: 110 to <130 mm …
This case report describes a 14 year old girl presenting with progressive left jaw swelling …
This Clinical Problem-Solving case follows a 48-year-old man with diabetes and chronic kidney disease who …
This editorial discusses the findings and implications of the GRADE trial, which compared four glucose-lowering …
This perspective article critiques the stigmatizing language embedded in the ICD10 code for obesity (E66.01: …
This editorial discusses the challenges of managing type 1 diabetes in young children, emphasizing the …
The study investigates SARS-CoV-2 infection in patients with a history of Vaccine-Induced Immune Thrombotic Thrombocytopenia …
Vitamin D supplements are widely recommended for bone health, but their efficacy in preventing fractures …
Abstract:A 31 year old man presented with a 10 year history of progressive finger and …
An 83 year old man with a history of coronary artery disease, hypertension, and hyperlipidemia …
This perspective critiques state level bans on gender affirming care as a form of science …
This perspective article discusses the 2022 White House Conference on Hunger, Nutrition, and Health, where …
This study examines the incidence of myocarditis following BNT162b2 mRNA COVID-19 vaccination in Israel, where …
This double blind, randomized, placebo controlled trial evaluated the efficacy and safety of once weekly …
This letter describes three cases of refractory vaccine-induced immune thrombotic thrombocytopenia (VITT) following ChAdOx1 nCoV-19 …
This pooled analysis of the EMPEROR-Reduced and EMPEROR-Preserved trials evaluated the renal effects of empagliflozin …
This study examines the long-term complications of youth onset type 2 diabetes in participants from …
This brief report details the first successful transplantation of a genetically modified pig heart into …
Hyponatremia, the most common electrolyte abnormality, is frequently caused by the syndrome of inappropriate antidiuresis …
The EMPEROR-Preserved trial investigated empagliflozin's effects in 5988 patients with heart failure and preserved ejection …
this editorial critiques the utility of routine surveillance stress testing in asymptomatic patients post-percutaneous coronary …
This study investigated the role of GNAS mutations in severe childhood obesity and their impact on melanocortin …
This instructional video perspective features Drs. Louis Aronne, Ania Jastreboff, and Sriram Machineni discussing the …
The MASTER DAPT trial investigated the optimal duration of dual antiplatelet therapy (DAPT) in high-bleeding-risk …
This multicenter, randomized, crossover trial compared hybrid closed loop therapy (artificial pancreas) with sensor augmented …
Frostbite, a tissue injury caused by extreme cold exposure, has historically affected military personnel and …
This article reviews strategies to reduce cardiovascular risk in patients with type 2 diabetes, emphasizing …
This editorial discusses the role of sacubitril-valsartan (an angiotensin receptor–neprilysin inhibitor, ARNI) in heart failure …
This multicenter, randomized trial compared routine functional testing (nuclear stress testing, exercise electrocardiography, or stress …
An 81 year old man with a history of a nonfunctioning pituitary macroadenoma presented with …
This perspective examines the conflict between state level bans on gender affirming care (e.g., Florida’s …
This phase 3 randomized trial evaluated whether thyroidectomy without postoperative radioiodine (¹³¹I) ablation is noninferior …
The editorial discusses the potential benefits of chlorthalidone in managing hypertension in advanced chronic kidney …
This multicenter randomized trial evaluated the efficacy of intermittently scanned continuous glucose monitoring (isCGM; FreeStyle …
This 13 week multicenter randomized trial evaluated the efficacy and safety of an insulin only …
This Images in Clinical Medicine entry describes a 34 year old woman with obesity and untreated diabetes …
This editorial discusses advancements in diabetes management, particularly the use of Automated Insulin Delivery (AID) …
This open-label, cluster-randomized trial in rural China investigated the effects of a salt substitute (75% …
This editorial reviews the evolving landscape of volume management in heart failure, spotlighting the ADVOR …
This editorial examines the evolving landscape of obesity treatment, highlighting the limitations of traditional approaches …
This editorial discusses myocarditis as a rare potential side effect of mRNA COVID-19 vaccines, particularly …
This clinical decision feature presents opposing viewpoints on screening for atrial fibrillation (AF) in an …
This editorial discusses the application of step therapy, a cost control strategy where lower cost …
This Images in Clinical Medicine case describes a 27 year old man with obesity and high fat …
This multicenter randomized trial investigated whether hybrid closed loop insulin therapy could preserve residual C …
This randomized trial compared lower and higher glycemic criteria for diagnosing gestational diabetes (GDM) in …
This correspondence reports long-term outcomes (7.2 and 6.8 years) of MC4R agonist (setmelanotide) treatment in …
A 25 year old woman with severe obesity (BMI 57) presented with blurred vision, headaches, …
This multicenter, open label, randomized controlled trial evaluated the efficacy and safety of an open …
The study compared the efficacy and safety of rivaroxaban versus vitamin K antagonist therapy in …
The POISE-3 trial evaluated the effects of tranexamic acid versus placebo in patients undergoing noncardiac …
This Clinical Problem Solving article discusses the diagnostic and management approach to a patient with …
This clinical decision feature presents a 71 year old postmenopausal woman with osteoporosis (femoral neck …
This perspective article condemns White supremacist attacks on antiracist health equity efforts, exemplified by a …
A newborn girl was admitted with severe neonatal hypoglycemia. Imaging revealed a presacral mass diagnosed …
This editorial compares the use of fractional flow reserve (FFR) and intravascular ultrasonography (IVUS) to …
The ENVISAGE-TAVI AF trial compared the efficacy and safety of edoxaban with vitamin K antagonists …
The EMPA KIDNEY trial evaluated the efficacy and safety of empagliflozin in 6609 patients with …
This editorial explores the potential of xenotransplantation as a solution to the shortage of human …
This multicenter, randomized clinical trial compared the effectiveness of four glucose lowering medications (insulin glargine, …
This editorial discusses the evolving role of radioiodine therapy in low risk differentiated thyroid cancer …
This correspondence reports a fatal case of vaccine-induced immune thrombocytopenia and thrombosis (VITT) following administration …
This article explores how individualistic cultural frameworks in the U.S. may exacerbate racial and ethnic …
This Case Records article describes a 17-year-old male with chest pain, syncope, and elevated cardiac …
This editorial analyzes the PROMINENT trial, which evaluated pemafibrate a selective PPARα modulator for cardiovascular …
This editorial discusses the Salt Substitute and Stroke Study (SSaSS), a large-scale trial involving 20,995 …
Among patients with chronic kidney disease (CKD) undergoing dialysis, anemia is common and associated with …
This editorial discusses the groundbreaking transplantation of a genetically modified pig heart into a human …
This prospective, multicenter, nonrandomized trial evaluated the safety and efficacy of a novel extravascular implantable …
This phase 3, randomized, placebo controlled trial evaluated the efficacy and safety of once weekly …
This editorial critiques the diagnostic thresholds for gestational diabetes mellitus (GDM) in light of the …
The BEST-CLI trial was a multicenter, randomized study evaluating surgical versus endovascular revascularization for chronic …
Retatrutide (LY3437943) is a triple agonist of the glucose-dependent insulinotropic polypeptide (GIP), glucagon like peptide …
This editorial reflects on two decades of the polypill concept originating with Wald and Law …
This editorial discusses the safety of testosterone-replacement therapy (TRT) in older men with hypogonadism, focusing …
This clinical image report describes a 58-year-old man with coronary artery disease who presented with …
A 68 year old man with type 2 diabetes presented with dysuria, hematuria, and passage …
This image-based case report describes a 64-year-old man with well-controlled rheumatoid arthritis who presented with …
This perspective article examines the Texas directive issued by Governor Greg Abbott in February 2022, …
This perspective emphasizes the urgent need to cultivate a new generation of clinician innovators who …
This clinical decision feature explores the management of hyperglycemia in a hospitalized 72 year old …
This perspective piece recounts the author's personal experience as a queer and trans individual seeking …
This review article examines the pathophysiology, clinical presentation, and management of spontaneous intracerebral hemorrhage (ICH), …
This article reviews emerging evidence challenging the perceived safety of artificial sweeteners, focusing on sucralose …
This clinical practice article reviews evidence based strategies for managing glycemia in children with type …
In this perspective piece, Dr. Howard Holtz highlights the critical need for effective communication and …
This observational study investigated the prevalence and effects of neutralizing autoantibodies against interleukin-1 receptor antagonist …
This multicenter randomized controlled trial evaluated the effects of immediate treatment versus deferred/no treatment for …
Obesity, the most common health problem in women of reproductive age, significantly increases risks for …
The PROMINENT trial assessed whether pemafibrate, a selective PPARα modulator could reduce cardiovascular events in …
This study analyzed the incidence of chronic kidney disease (CKD) among 654,459 adults with diabetes …
This multicenter, double blind, randomized, placebo-controlled trial investigated the cardiovascular effects of semaglutide in 17,604 …
This multicenter, randomized controlled trial investigated the effects of tight glucose control (target: 80–110 mg/dL) …
This phase 3 randomized controlled trial (SECURE) evaluated the efficacy of a cardiovascular polypill containing …
This registry-based analysis examined racial and ethnic disparities in the provision of bystander cardiopulmonary resuscitation …
The AMPLITUDE-O trial evaluated the cardiovascular and renal outcomes of efpeglenatide, a weekly glucagon-like peptide-1 …
This editorial evaluates the Diuretic Comparison Project (DCP)—a pragmatic, randomized trial comparing chlorthalidone and hydrochlorothiazide …
This multimedia instructional article explains how focused cardiac ultrasonography (FCU) can be used at the …
This editorial explores an innovative experimental approach to post-mortem tissue revival and its implications for …
This editorial explores the clinical implications of the TTM and TTM2 trials evaluating targeted temperature …
This observational study analyzed the incidence and clinical outcomes of myocarditis in adolescents (ages 12–15) …
This editorial discusses the findings of the CLOuD trial, which investigated whether hybrid closed loop …
This phase 1 dose-escalation trial assessed the safety, pharmacodynamics, and efficacy of olpasiran, a small …
This phase 2 trial evaluated the efficacy and safety of baxdrostat, a selective aldosterone synthase …
This multicenter, randomized, placebo-controlled trial (STRESS) evaluated the prophylactic use of methylprednisolone in infants (<1 …
This editorial interprets findings from the BEST-CLI trial, which compared surgical and endovascular revascularization in …
This phase 3 randomized trial (SOLOIST-WHF) evaluated sotagliflozin, a dual SGLT1/SGLT2 inhibitor in patients with …
This editorial evaluates the STOP-ACEi randomized controlled trial, which assessed the clinical impact of continuing …
This Clinical Problem-Solving article details the diagnostic journey of a 50-year-old woman presenting with chest …
Posterior reversible encephalopathy syndrome (PRES) is an acute or subacute neurologic condition characterized by headache, …
This article examines the precarious constitutional right to health care for incarcerated individuals in the …
This study describes two novel homozygous leptin variants (P64S and G59S) identified in unrelated children …
This article discusses the persistent high costs of insulin in the United States and evaluates …
This editorial discusses the findings of a study by Chen et al. (2023) involving 315 …
This multicenter, open-label randomized controlled trial (STOP ACEi) investigated whether discontinuing renin–angiotensin system (RAS) inhibitors—ACE …
This pragmatic trial evaluated the effectiveness of an electronic health record (EHR) based algorithm combined …
This study pooled individual level data from 112 cohort studies across 34 countries (1,518,028 participants; …
This correspondence reports the successful use of RZ358, a novel human anti insulin receptor monoclonal …
This GRADE trial analysis compared microvascular and cardiovascular outcomes across four glucose-lowering agents: glargine, glimepiride, …
A 49-year-old woman with a history of Graves’ disease presented with violaceous, nonpitting, indurated nodules …
This correspondence presents findings from a phase 2b study evaluating the efficacy and safety of …
This image-based case report describes a 79-year-old woman referred for cardiovascular evaluation due to a …
This BOX trial subanalysis evaluated the effects of two oxygenation targets restrictive (PaO₂ 68–75 mm …
The STEP HFpEF trial investigated the efficacy of semaglutide (2.4 mg weekly) in 529 patients …
This correspondence reports a rare case of a 57 year old man with prostate cancer …
This image-based case report describes a 75-year-old man with facial erythema initially suspected as …
This editorial reviews the INVICTUS trial, a randomized study evaluating oral anticoagulants in patients with …
This editorial discusses the challenges of treating resistant hypertension, a condition affecting 20% of hypertensive …
This multicenter, population-based randomized trial, DANCAVAS, examined whether comprehensive cardiovascular screening in men aged 65–74 …
This editorial explores the interplay between social determinants and the likelihood of receiving bystander cardiopulmonary …
This editorial analyzes the PROTECTED TAVR trial, which investigated whether cerebral embolic protection (CEP) devices …
This editorial highlights the global burden of cardiovascular disease (CVD), emphasizing modifiable risk factors such …
This randomized controlled trial (REVIVED-BCIS2) evaluated whether percutaneous coronary intervention (PCI) added to optimal medical …
This correspondence reports a case of a patient on empagliflozin (an SGLT2 inhibitor) who experienced …
This multicenter, randomized, double blind, placebo controlled trial evaluated the cardiovascular safety of testosterone replacement …
This article examines how the concept of "social contagion" has been historically weaponized to restrict …
This phase 2, randomized, double blind trial evaluated the efficacy and safety of the nonpeptide …
This editorial discusses the global obesity epidemic and its significant role in cardiovascular disease (CVD). …
This multicenter, cluster-randomized trial (DOSE VF) compared three defibrillation strategies standard defibrillation, vector-change (VC) defibrillation, …
Obesity is a complex medical condition influenced by genetics, environment, and psychosocial factors, yet treatment …
This multicenter, randomized controlled trial evaluated the efficacy of hybrid closed loop insulin therapy in …
This Clinical Decisions case feature explores hospital admission pathways for older adults with hip fracture, …
This editorial advocates for surgical occlusion of the left atrial appendage (LAA) during cardiac surgery …
This editorial discusses the challenges of treating childhood obesity, particularly cases involving leptin resistance. It …
This case report describes an 18year old male with poorly controlled type 1 diabetes (glycated …
This phase 2b, randomized, double-blind, placebo-controlled trial evaluated the efficacy and safety of pegozafermin, a …
This multimedia educational feature outlines key principles in the diagnosis and management of atrial fibrillation …
The GRADE trial compared four glucose-lowering medications: insulin glargine, glimepiride, liraglutide, and sitagliptin, when added …
The PROTECTED TAVR trial, a multicenter, randomized study, evaluated whether cerebral embolic protection (CEP) using …
his double-blind, randomized trial (BOX) compared mean arterial blood pressure targets of 77 mm Hg …
This prospective observational study (DePPaRT) evaluated the incidence and timing of resumption of cardiac electrical …
This correspondence reports the successful use of alpelisib, a PI3 kinase inhibitor, to treat intractable …
The ADVOR trial, a multicenter, double-blind, placebo-controlled study, assessed whether intravenous acetazolamide improves decongestion in …
This phase 2, multicenter, randomized, placebo-controlled trial evaluated the efficacy and safety of tirzepatide, a …
This subtrial of the TRAVERSE study evaluated the effect of testosterone therapy on fracture risk …
This editorial discusses the REHAB-HF trial, which evaluated tailored exercise rehabilitation for frail, elderly …
This phase 2, randomized, placebo controlled trial investigated whether baricitinib, a Janus kinase (JAK) inhibitor, …
This editorial reviews findings from the DELIVER trial, which evaluated dapagliflozin an SGLT2 inhibitor in …
This editorial discusses advancements in managing chronic kidney disease (CKD), focusing on the role of …
This editorial evaluates therapeutic choices following metformin initiation in patients with type 2 diabetes who …
This randomized trial (EARLY-AF) compared cryoballoon catheter ablation with antiarrhythmic drug therapy as first-line treatment …
A 34 year old man presented with diabetic ketoacidosis and coarse facial features, including frontal …
A 70 year old woman with long standing type 1 diabetes presented with calloused and …
Abstract:This editorial discusses the potential of thyroid hormone receptor beta (THR-β) agonists, such as resmetirom, …
This brief report presents five cases of vaccine-induced immune thrombotic thrombocytopenia (VITT) in previously healthy …
This perspective article reflects on how the Covid-19 pandemic catalyzed innovations in care delivery, using …
This pragmatic, multicenter trial the Diuretic Comparison Project, compared chlorthalidone and hydrochlorothiazide in preventing major …
This phase 3, double-blind randomized trial (STEP 1) evaluated once-weekly subcutaneous semaglutide (2.4 mg) versus …
This postmortem study investigated sudden cardiac death and myocardial fibrosis in HIV-positive individuals using forensic …
This perspective article describes efforts to increase diversity in the University of Utah Family Medicine …
This editorial discusses the role of aldosterone in treatment resistant hypertension (defined as blood pressure …
This multicenter, double-blind randomized trial (SCORED) evaluated the efficacy of sotagliflozin, a dual SGLT1/SGLT2 inhibitor …
This editorial discusses the GALACTIC-HF trial results evaluating omecamtiv mecarbil, a cardiac myosin activator that …
This correspondence reports the rapid cardiovascular effects of belzutifan, a hypoxia inducible factor 2α (HIF …
This editorial examines the STEP 1 trial evaluating once-weekly subcutaneous semaglutide in adults with overweight …
This patient-facing multimedia article explains atrial fibrillation (AF) the most common sustained cardiac arrhythmia its …
This review article examines the health effects of endocrine disrupting chemicals (EDCs) derived from fossil …
This cross-sectional analysis evaluated U.S. adults with diagnosed diabetes participating in NHANES (1999–2018) to assess …
This phase 2, double blind, randomized, placebo controlled trial evaluated the effect of lixisenatide, a …
This editorial examines the rapid expansion and reimbursement of remote patient monitoring (RPM) services, accelerated …
This randomized, placebo-controlled trial (TIPS-3) investigated whether a fixed-dose polypill comprising simvastatin, atenolol, hydrochlorothiazide, and …
This phase 2 trial evaluated the efficacy of ponsegromab, a humanized monoclonal antibody targeting growth …
This editorial reflects on the ADAPTABLE trial, which evaluated 81 mg versus 325 mg daily …
This correspondence presents 10 year outcomes from the Teen-LABS study, a prospective multicenter observational cohort …
This multicenter randomized controlled trial (REHAB-HF) assessed the impact of a transitional, tailored, progressive physical …
This multinational cohort study from the PURE trial examines the relationship between dietary glycemic index …
This image-based case report describes a 58-year-old man who experienced intermittent dizziness and palpitations exclusively …
This image-based case report describes a 67-year-old woman who presented with fatigue and anorexia …
This study evaluated the efficacy and safety of once weekly semaglutide (2.4 mg) in patients …
This editorial analyzes findings from the FLOWER-MI trial comparing fractional flow reserve (FFR)-guided versus angiography-guided …
This perspective article marks the 50th anniversary of the National Academy of Medicine and traces …
This complex case report describes a 68-year-old man who presented with progressive delirium, renal insufficiency, …
This randomized multicenter trial (FLOWER-MI) compared fractional flow reserve (FFR)-guided versus angiography-guided complete revascularization in …
This phase 3 trial evaluated the efficacy of crinecerfont, an oral corticotropin releasing factor type …
This editorial discusses the polypill strategy as a transformative approach for improving global cardiovascular health. …
This editorial introduces a new review article series focused on nutrition in medicine, addressing the …
This correspondence presents a retrospective analysis examining the vascular effects of magrolimab a CD47-blocking macrophage …
A 55 year old woman with a significant smoking history presented with a 1.5 year …
This case report describes a 43 year old woman with an 8 year history of …
This editorial synthesizes emerging data on vaccine-induced immune thrombotic thrombocytopenia (VITT) following SARS-CoV-2 vaccination, particularly …
This case series describes 23 patients who developed thrombosis and thrombocytopenia 6–24 days after receiving …
This image-based case report details an 83-year-old woman who presented with acute right-sided tongue swelling, …
This case report describes a 3 year old boy presenting with lateral bowing of the …
This multicenter randomized trial assessed whether therapeutic-dose heparin improves outcomes in hospitalized noncritically ill Covid-19 …
This clinical decision article explores whether a hepatologist consultation is warranted for a 58 year …
This perspective highlights evidence based, population level strategies to prevent childhood obesity while advancing health …
This review article examines the prevention of cardiovascular disease (CVD) in patients with type 1 …
This comprehensive review outlines current strategies for managing antithrombotic therapy following acute coronary syndromes (ACS). …
This image-based case report features a 64-year-old woman with hypertension who presented with chest pain …
This review article provides an overview of contemporary nutritional concepts, focusing on energy and macronutrients …
This Clinical Problem-Solving article presents the diagnostic and therapeutic journey of a 61-year-old man scheduled …
This comprehensive review explores the relationship between pollution and cardiovascular disease, emphasizing pollution as …
This randomized controlled trial (TTM2) evaluated whether targeted hypothermia (33℃) improves survival and neurologic outcomes …
This editorial evaluates the QWINT-2 trial results, which demonstrate the noninferiority of once-weekly insulin efsitora …
Chronic venous insufficiency (CVI) is a prevalent condition characterized by venous hypertension, leading to symptoms …
This Clinical Problem-Solving case details the diagnostic journey of a 38-year-old woman with recurrent early-onset …
This Clinical Practice article reviews glucose-lowering therapies in type 2 diabetes with a focus on …
This correspondence reports five-year outcomes from the Gore REDUCE trial, comparing patent foramen ovale (PFO) …
This editorial highlights the transformative potential of tirzepatide, a dual GLP-1/GIP receptor agonist, for treating …
This randomized multicenter trial (BASICS) assessed the efficacy of endovascular therapy versus standard medical management …
This image-based case report describes a 72-year-old woman who presented with epigastric pain, nausea, dyspnea, …
This correspondence reports two adult cases of histologically confirmed myocarditis occurring within 2 weeks of …
This editorial discusses the promise of dual agonists tirzepatide (GLP-1/glucose-dependent insulinotropic polypeptide receptor agonist) and …
This editorial evaluates the role of early catheter ablation specifically cryoballoon pulmonary vein isolation as …
This article presents the rationale behind the FDA Center for Drug Evaluation and Research's proposal …
This editorial discusses the pivotal role of semaglutide, a GLP-1 receptor agonist, in managing diabetic …
This image-based case report describes a 54-year-old woman who presented with palpitations that were relieved …
This article reviews the evaluation and management of degenerative rotator cuff disorders, which are common …
This editorial highlights the promising role of GLP 1 receptor agonists, particularly semaglutide, in managing …
This article highlights recent advances in modeling human cardiac development using organoids. The featured study …
This editorial discusses advances in treating congenital adrenal hyperplasia (CAH), a disorder primarily caused by …
This case report describes a 46 year old woman with hyperglycemia refractory to high dose …
Chronic diseases, including heart disease, cancer, diabetes, and liver disease, account for seven of the …
This correspondence describes cases of vaccine-induced thrombocytopenia (VIT) with severe headache occurring 5 to …
This editorial reviews findings from the BASICS and BEST trials, which evaluated endovascular therapy for …
This final report of the SPRINT randomized trial presents comprehensive follow-up data comparing intensive …
This perspective examines the U.S. Supreme Court’s 2020 decision in June Medical Services v. Russo, which …
This case report describes a 53-year-old man presenting with acute lower limb paralysis and fever …
This phase 2, double blind, randomized, placebo-controlled trial evaluated the efficacy and safety of Lu …
This brief case report highlights a rare manifestation of Quincke’s sign in a 21-month-old boy …
A 2 year old boy presented with recurrent seizures and was found to have neuromuscular …
This editorial reviews emerging data on sotagliflozin, a dual inhibitor of sodium-glucose cotransporters 1 and …
This editorial discusses the clinical trial by Ashina et al. on Lu AG09222, a monoclonal …
This perspective reviews the evolving regulatory and safety landscape surrounding drug-coated devices (DCDs)—specifically paclitaxel-coated balloons …
This editorial reviews evolving evidence on anticoagulation strategies for hospitalized Covid-19 patients, emphasizing the role …
This randomized, double-blind trial (EMPEROR-Preserved) assessed empagliflozin versus placebo in 5988 patients with class II–IV …
Nonalcoholic steatohepatitis (NASH) is a progressive liver disease with no approved treatment. Resmetirom is an …
This phase 3 trial (SURPASS-2) compared the efficacy and safety of once-weekly tirzepatide—a dual glucose-dependent …
This perspective explores how the opioid epidemic has reshaped the epidemiology and care of infective …
This Images in Clinical Medicine entry reports a rare case of complex umbilical cord knotting in monochorionic, monoamniotic twins …
Abstract:This phase 2 trial evaluated the efficacy and safety of survodutide, a dual glucagon receptor …
This case report describes a 37-year-old woman with abdominal pain and progressive aortic dilatation. Initial …
This article reviews the application of adenine base editing (ABE) as a therapeutic strategy for …
This editorial discusses findings from the TRAVERSE trial, which examined the effects of testosterone therapy …
This phase 3 randomized trial (ASCEND-ND) compared oral daprodustat, a hypoxia-inducible factor prolyl hydroxylase inhibitor, …
This large, pragmatic randomized trial (ADAPTABLE) compared the effectiveness and safety of two aspirin dosing …
This multicenter randomized trial (STEP) evaluated whether intensive systolic blood pressure control (target 110 to …
This phase 1–2 clinical trial investigated SPK-8011, an adeno-associated viral (AAV) vector designed to …
This phase 3 randomized trial (GALACTIC-HF) evaluated omecamtiv mecarbil, a selective cardiac myosin activator, in …
This editorial discusses the Vitamin D Antenatal Asthma Reduction Trial (VDAART), which investigated whether high-dose vitamin …
This international multiplatform randomized trial investigated whether therapeutic-dose heparin improves outcomes in critically ill patients …
This perspective article critiques the U.S. chronic-disease care system through lessons revealed during the Covid-19 …
This study evaluated the use of MinION long-read nanopore sequencing for preimplantation genetic testing for …
This Clinical Problem-Solving case details the diagnostic journey of a 67-year-old man who presented with …
This case report chronicles the diagnostic and management journey of a 26-year-old pregnant woman with …
This observational study assessed the safety profile of the BNT162b2 mRNA Covid-19 vaccine across a …
This multicenter randomized trial evaluated the effect of immediate coronary angiography versus delayed/selective angiography in …
This perspective article explores the ethical and public health considerations surrounding recommendations to delay pregnancy …
This case report details the clinical journey of a 16-year-old boy presenting with headache, abdominal …
This original research article identifies a novel circulating noncoding RNA, hsa-Chr8:96, as a biomarker for …
This editorial reviews findings from the EMPEROR-Preserved trial, which examined the effects of SGLT2 inhibitors—originally …
This editorial discusses the FEMME trial, which compared uterine-artery embolization (UAE) and myomectomy for treating …
This correspondence describes therapeutic plasma exchange (TPE) as a potential treatment for vaccine-induced immune thrombotic …
Respiratory syncytial virus (RSV) is a leading cause of severe lower respiratory tract infections in …
This review article explores the convergence of immune engineering and genome editing in advancing regenerative …
This correspondence investigates the potential immunological link between SARS-CoV-2 vaccination and vaccine-induced immune thrombotic thrombocytopenia …
This editorial emphasizes the importance of contextualizing vaccine safety data during a pandemic. It revisits …
This correspondence presents interim safety data from the Sisonke phase 3b implementation trial of the …
This perspective article examines the implications of Idaho’s Fairness in Women’s Sports Act, which bars transgender …
This interactive editorial explores antibiotic treatment strategies for methicillin-sensitive Staphylococcus aureus endocarditis in a patient …
This case describes an 81-year-old man with longstanding atrial fibrillation who presented after a fall …
This editorial explores evolving strategies for post–percutaneous coronary intervention (PCI) antithrombotic therapy, especially in patients …
This multicenter randomized trial compared uterine artery embolization (UAE) and myomectomy in 254 women with symptomatic uterine fibroids who …
This article discusses the clinical implications of mitochondrial replacement techniques, including their use for preventing …
This correspondence evaluates platelet factor 4 (PF4) immunoassay performance in diagnosing vaccine-induced immune thrombotic thrombocytopenia …
This editorial discusses myocarditis as a rare but notable side effect associated with the BNT162b2 …
This study investigated the long-term effects of prenatal vitamin D supplementation on asthma and recurrent …
This multicenter, double blind, randomized controlled trial evaluated the efficacy of prophylactic tranexamic acid (1 …
This retrospective cohort study evaluated myocarditis incidence following administration of the BNT162b2 mRNA Covid-19 vaccine …
This review article discusses point-of-care ultrasonography (POCUS), which refers to ultrasonographic imaging performed and …
Limited data suggest that higher hemoglobin thresholds for red cell transfusions may reduce the risk …
This Images in Clinical Medicine entry describes a case of twin anemia polycythemia sequence (TAPS) in monochorionic, diamniotic twins …
This editorial explores findings from the STEP trial conducted in China, which confirmed cardiovascular benefits …
This retrospective cohort study from Israel examined the incidence of myocarditis following the BNT162b2 mRNA …
This case report describes a 30 year old pregnant woman who presented at 34 weeks …
This editorial analyzes the discordant results of the GALILEO trial, which evaluated rivaroxaban versus antiplatelet …
This large cluster-randomized trial (SSaSS) enrolled 20,995 adults from 600 rural Chinese villages primarily individuals …
This perspective article examines the potential consequences of a Supreme Court challenge to the Affordable …
Bacterial vaginosis (BV) affects 15–50% of women of reproductive age, with high recurrence rates after …
Syphilis, caused by Treponema pallidum, has resurged in the United States, reaching levels not seen in …
This phase 2 randomized trial evaluated the efficacy and safety of milvexian, an oral Factor …
This case report describes a 27 year old primigravid woman presenting with new-onset diabetes, hypertension, …
This randomized clinical trial compares milrinone and dobutamine in patients with cardiogenic shock. The study …
BACKGROUND: The prevalence of type 2 diabetes in youth is increasing, but little is known …
This clinical review examines the benefits and risks of hormone therapy for postmenopausal women, focusing …
Abdominal aortic aneurysms are defined as having an aortic diameter of more than 3 cm. …
This phase 3 randomized controlled trial (FIGARO-DKD) evaluated finerenone—a selective nonsteroidal mineralocorticoid receptor antagonist in …
This multicenter, randomized, noninferiority trial compared two glucose threshold values for treating asymptomatic moderate hypoglycemia …
This perspective article argues against the FDA’s proposed withdrawal of approval for 17 alpha hydroxyprogesterone …
This nationwide Swedish cohort study evaluated the association between quadrivalent HPV vaccination and the risk …
This perspective examines the evolving landscape of health coverage and care for transgender individuals in …
his study evaluated the diagnostic yield of exome sequencing in 127 consecutive cases of unexplained …
This Clinical Decisions article presents a 58-year-old woman with epigastric pain, shoulder and jaw discomfort, …
This editorial evaluates the clinical implications of using soluble urokinase plasminogen activator receptor (suPAR) levels …
This review article outlines the mechanisms, diagnosis, and management strategies for heparin resistance, defined as …
This editorial explores the therapeutic potential of in vivo CRISPR-Cas9 gene editing for transthyretin amyloidosis …
This perspective article examines the growing influence of Catholic hospital mergers in the U.S. healthcare …
This case report describes a 29 year old primigravida presenting at 33 weeks’ gestation with …
This correspondence presents findings from a follow-up study of 35 patients in Germany with vaccine-induced …
This editorial examines the role of genomic sequencing in understanding the genetic causes of stillbirth, …
This editorial reviews the CLICK trial, which tested chlorthalidone in patients with stage 4 chronic …
This article critically examines the use of polygenic scores for embryo selection (ESPS), a service …
A 19 year old woman presented with acute abdominal pain and was diagnosed with left …
This multicenter randomized trial (MASTER DAPT) evaluated abbreviated vs. standard-duration dual antiplatelet therapy (DAPT) in …
This editorial examines the outcomes and clinical implications of the PARADISE-MI trial, which assessed sacubitril–valsartan …
This correspondence describes a pooled patient-level analysis of the EMPEROR-Reduced and EMPEROR-Preserved trials, investigating the …
This perspective examines the surge in intimate partner violence (IPV) during the Covid-19 pandemic, exacerbated …
This article explores how abortion access is impacted not only by clinic closures, but also …
This phase 3 randomized controlled trial (AMPLITUDE-O) evaluated efpeglenatide, a weekly GLP-1 receptor agonist, in …
This Clinical Problem-Solving article presents a diagnostically complex case involving a 75-year-old man with a …
This Clinical Problem-Solving article presents a diagnostically complex case involving a 75-year-old man with a …
This Clinical Decisions article presents a case vignette of a 74-year-old man with persistent atrial …
This editorial evaluates a trial by Jafar et al. on managing hypertension in rural South …
This prospective cohort study described 220 patients in the United Kingdom diagnosed with vaccine-induced immune …
This study describes a patient with severe germline VHL deficiency due to a novel synonymous …
This double-blind, placebo-controlled trial (CLICK) evaluated chlorthalidone in 160 patients with stage 4 chronic kidney …
This Case Records report details a 47-year-old man presenting with recurrent left-sided head and neck …
This multicenter case series describes 18 patients with confirmed Covid-19 who presented with ST-segment elevation …
This editorial reviews 5-year data from the PARTNER 2 cohort A trial comparing transcatheter aortic-valve …
This editorial reviews the Salt Substitute and Stroke Study (SSaSS), a cluster-randomized trial involving over …
This editorial reviews recent advances in incretin-based therapy for type 2 diabetes, focusing on tirzepatide …
This phase 2 trial evaluated the efficacy and safety of abelacimab—a monoclonal antibody that locks …
This randomized noninferiority trial compared the efficacy of levonorgestrel 52mg IUDs (LNG-IUD) and copper T380A …
This brief report outlines the clinical and laboratory responses to high-dose intravenous immune globulin (IVIG) …
This double-blind, randomized trial investigated venous thromboembolism (VTE) prophylaxis in 3,604 adults undergoing nonmajor orthopedic …
This phase 3 randomized, double-blind trial PARADISE-MI compared sacubitril–valsartan to ramipril in patients with acute …
This perspective explores the ethical and medical dilemmas in caring for patients with opioid use …
This case report describes a 26 year old woman who presented with recurrent hemoptysis coinciding …
In most stillbirth cases, causes remain undetermined despite evaluation. This study applied exome sequencing to …
A 34 year old woman presented with a history of persistent hyperglycemia since age 24, …
This study analyzed 118 pregnant women with Covid-19 in Wuhan, China (December 2019, march 2020), …
This Special Report evaluates cervical cancer screening methods based on a comprehensive review by the …
The PRAETORIAN trial was a randomized, noninferiority study comparing subcutaneous implantable cardioverter-defibrillators (S-ICDs) to transvenous …
This prospective, multicenter cohort study compared seizure frequency and antiepileptic drug (AED) adjustments in 351 …
This editorial notice issues an official Expression of Concern regarding a previously published study that …
This first-person narrative explores how the Covid-19 pandemic reshaped clinical decision-making, even for patients without …
This perspective article argues that abortion is an essential health service, particularly during the Covid-19 …
This Sounding Board article critiques the widespread adoption of preimplantation genetic testing for aneuploidy (PGT-A) …
This perspective article critiques Texas Senate Bill 8 (S.B. 8), which bans abortions after approximately …
This multicenter study investigated whether elevated levels of soluble urokinase plasminogen activator receptor (suPAR) predispose …
The placenta exhibits unique biological behaviors, including extensive clonal genetic mosaicism and somatic mutations similar …
This editorial analyzes the PRAETORIAN trial, a noninferiority study comparing transvenous implantable cardioverter-defibrillators (ICDs) with …
This editorial discusses the nuanced relationship between statin therapy and stroke prevention. While statins are …
This comprehensive review examines Down syndrome as the most common chromosomal condition associated with intellectual …
This study investigated the role of PNLDC1, a protein critical for piRNA processing, in male …
This perspective piece celebrates the life and legacy of Dr. Rebecca Crumpler (1831–1895), the first …
This editorial discusses the optimal timing of surgical intervention for aortic stenosis, referencing a trial …
This perspective examines the collateral impact of the Covid-19 pandemic on patients with non-Covid-related conditions. …
This editorial explores evolving pathophysiologic insights into heart failure with preserved ejection fraction (HFpEF). Once …
This Perspective article evaluates the 2021 reauthorization of the Child Abuse Prevention and Treatment Act …
This comprehensive review explores the complex intersection of chronic obstructive pulmonary disease (COPD) and systemic …
This article critiques the U.S. Supreme Court’s 2021 decision in FDA v. ACOG, which reinstated in …
This correspondence investigates the correlation between the Covid-19 outbreak and out-of-hospital cardiac arrest (OHCA) in …
This Clinical Problem-Solving case chronicles the diagnostic challenges surrounding a 64-year-old heart transplant recipient who …
This clinical image report describes a 33-year-old man who developed palpitations and syncope during a …
This phase 3, randomized, double-blind, placebo-controlled trial (VICTORIA) evaluated the efficacy and safety of vericiguat, …
Two phase 3 randomized trials ORION-10 and ORION-11 evaluated inclisiran, a small interfering RNA (siRNA) …
A 50-year-old woman with a history of bicuspid cardiac transplantation presented with acute cellular rejection, …
This clinical image presents a rare case of pelvic splenosis in a 34 year old …
This phase 3, randomized, double-blind, placebo-controlled trial (VICTORIA) evaluated the efficacy and safety of vericiguat, …
This perspective outlines Egypt’s landmark public health initiative the 100 Million Healthy Lives program which …
This clinical practice article addresses the evaluation and management of stress urinary incontinence (SUI) in …
This editorial discusses the molecular basis and therapeutic promise of cyclic GMP modulation in heart …
This study conducted active surveillance for multisystem inflammatory syndrome in children (MIS-C) across 26 U.S. …
This randomized trial evaluated rivaroxaban (10 mg daily) versus antiplatelet therapy in 1,644 patients without …
reatment for patients with recurrent ovarian cancer has been mainly based on systemic therapy. The …
This correspondence describes the diagnosis and treatment of a left internal jugular vein thrombosis in …
This multinational prospective study examined infection rates associated with reused and resterilized cardiac implantable electronic …
This multicenter, randomized, single-blind trial compared the safety and effectiveness of polymer-based zotarolimus-eluting stents versus …
This substudy of the GALILEO trial investigated whether a rivaroxaban-based antithrombotic strategy reduced subclinical leaflet-motion …
This randomized, double-blind, placebo-controlled phase 2 trial assessed the efficacy and safety of AKCEA-APO(a)-LRx, an …
This multicenter retrospective study evaluated hospital admission rates for acute coronary syndrome (ACS) at 15 …
This large population-based case-control study evaluated whether angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers …
This clinical image depicts a rare case of omental endometriosis in a 37 year old …
This comprehensive clinical review discusses native-valve infective endocarditis (IE), emphasizing its evolving epidemiology, pathogenesis, and …
This image-based clinical report describes a male neonate born at 35 weeks’ gestation with a …
This clinical image report describes a 61-year-old man with stage IIIB squamous-cell lung carcinoma who …
This personal narrative recounts the author’s experience as a Black, queer, nonbinary medical student navigating …
This clinical image presents a case of placenta increta in a 26-year-old woman at 32 …
A multisystem inflammatory syndrome in children (MIS-C) is associated with coronavirus disease 2019 (COVID-19). The …
his study presents preliminary safety data from U.S. surveillance systems (v-safe, v-safe pregnancy registry, and …
This phase 3, double-blind, randomized trial evaluated the efficacy and safety of inclisiran a small …
Aldosterone plays a critical role in the progression of chronic kidney disease (CKD), particularly in …
This randomized trial (ISCHEMIA-CKD) assessed outcomes in 777 patients with stable coronary artery disease, advanced …
This multicenter randomized trial compared early aortic-valve replacement with guideline-recommended conservative care in 145 asymptomatic …
This phase 3, double blind trial evaluated pembrolizumab combined with platinum based chemotherapy (with/without bevacizumab) …
A male neonate born at 37 weeks of gestation presented with closed gastroschisis, a rare …
This article explores the development and potential applications of human cardiac organoids ("cardioids") for studying …
This large, multicenter, randomized trial (ISCHEMIA) evaluated whether an initial invasive strategy (angiography and revascularization …
This editorial discusses the safety and efficacy of mRNA COVID-19 vaccines (Pfizer-BioNTech and Moderna) in …
This poignant perspective piece recounts the author’s encounter with "Ms. Omega One," an unidentified young …
This multicenter randomized trial assessed long-term outcomes of transcatheter aortic-valve replacement (TAVR) versus surgical aortic-valve …
This editorial highlights the emergence of a novel pediatric disorder termed multisystem inflammatory syndrome in …
This multicenter, randomized, controlled trial compared the cumulative live Birth rate between subfertile women undergoing …
This editorial examines the ongoing debate around the safety of renin–angiotensin–aldosterone system (RAAS) inhibitors such …
In this randomized, single-center trial, 84 adults with chronic leg edema and recurrent cellulitis were …
The ISCHEMIA-CKD trial evaluated health-related quality of life in patients with stable ischemic heart disease, …
This secondary analysis from the ISCHEMIA trial compared health-related quality-of-life outcomes between an invasive strategy …
This personal narrative exposes the challenges faced by a Black female applicant during OB/GYN residency …
This editorial discusses bleeding complications in patients undergoing transcatheter aortic-valve implantation (TAVI), focusing on the …
This multicenter, double-blind trial evaluated the efficacy of CMV hyperimmune globulin in preventing congenital CMV …
This multinational observational study analyzed 8,910 hospitalized Covid-19 patients (December 2019–March 2020) to assess associations …
This editorial examines the ongoing debate over diagnostic approaches for gestational diabetes mellitus (GDM), contrasting …
This correspondence reports a concerning rise in congenital syphilis cases among U.S. infants born in …
This study evaluated the impact of the Laparoscopic Approach to Cervical Cancer (LACC) Trial, which …
This case report describes a 26 year old pregnant woman with a monochorionic, diamniotic twin …
This correspondence presents data from over 11,000 cases of amyloidosis diagnosed between 1987 and 2019 …
A 29 year old pregnant woman with undifferentiated connective tissue disease presented at 26 weeks …
This editorial discusses the challenges of nutritional management in extremely preterm infants, focusing on the …
This editorial discusses findings from the Tracheal Occlusion to Accelerate Lung Growth (TOTAL) trial, which …
A 54 year old woman presented with a 2 month history of fevers, weight loss, …
This pragmatic, randomized clinical trial compared two screening approaches for gestational diabetes mellitus (GDM): the …
A 26 year old woman presented with a painful, firm axillary mass that developed two …
This editorial discusses the evolving role of direct oral anticoagulants (DOACs) for treating venous thromboembolism …
An 84-year-old man developed sudden severe pain and weakness in his right arm 7 days …
This personal perspective recounts the author’s experience seeking fertility preservation at a clinic advertised as …
his case report describes a 33 year old pregnant woman with ulcerative colitis who presented …
This correspondence reports on five critically ill COVID-19 patients who developed acute cor pulmonale (right …
This letter to the editor explores the indirect impact of the COVID-19 pandemic on stroke …
This commentary reviews pivotal findings from a study on the cellular basis of congenital heart …
This study identifies biallelic mutations in the WLS gene, encoding the Wnt ligand secretion mediator, as the …
This review article examines the pervasive issue of obesity among women of reproductive age and …
This editorial examines the pioneering application of in utero enzyme replacement therapy (ERT) for infantile onset Pompe’s disease, …
A 44-year-old woman with mild COVID-19 symptoms developed acute chest pain, dyspnea, and refractory cardiogenic …
This randomized trial compared oral anticoagulation (OAC) alone versus OAC plus clopidogrel for 3 months …
This study investigated the impact of left-digit bias (cognitive tendency to categorize continuous variables by …
This study evaluates a noninvasive method for comprehensive fetal exome screening using circulating cell-free DNA …
This perspective article examines the escalating role of pharmaceuticals in safeguarding reproductive rights following the …
BACKGROUND: Randomized trials have shown that paclitaxel-coated devices are more effective than uncoated devices for …
A 73-year-old man with a history of hypertension, diabetes, and atrial fibrillation presented during the …
This study analyzed UK electronic health records (1998–2016) to assess the impact of ACE inhibitors …
This editorial discusses the role of alcohol abstinence in managing atrial fibrillation (AF), referencing a …
This multinational, randomized trial compared oral apixaban with subcutaneous dalteparin for treating venous thromboembolism (VTE) …
BACKGROUND: Evolocumab, a fully human monoclonal antibody that targets proprotein convertase subtilisin-kexin type 9 (PCSK9), …
A 66-year-old man presented with dyspnea, leg swelling, fatigue, and weight loss. Imaging revealed a …
BACKGROUND: Finerenone, a nonsteroidal, selective mineralocorticoid receptor antagonist, reduced albuminuria in short-term trials involving patients …
BACKGROUND: The use of intensive lipid-lowering therapy, primarily through statin medications, is recommended following a …
This editorial discusses the promise of evinacumab, a monoclonal antibody against angiopoietin-like 3 (ANGPTL3), in …
BACKGROUND: Patients suffering from refractory hypercholesterolemia, characterized by persistently high low-density lipoprotein (LDL) cholesterol levels …
This editorial discusses the impact of the opioid crisis on pregnant individuals and their infants, …
BACKGROUND: Providing appropriate oral anticoagulant treatment for stroke prevention in very elderly patients with atrial …
BACKGROUND: The global burden of hypertension is steadily increasing, and the rates of blood pressure …
This review examines the neurologic outcomes of preterm birth, focusing on three major brain injuries …
Patients with familial hypercholesterolemia (FH), who experience severely elevated low-density lipoprotein (LDL) cholesterol from birth …
The Covid-19 pandemic has brought to light long-standing quality deficiencies within U.S. health care, building …
During the Covid-19 pandemic, there have been suggestions of a decrease in hospital presentations for …
BACKGROUND: Homozygous familial hypercholesterolemia is a genetic disorder characterized by the premature onset of cardiovascular …
Treatment approaches for atrial fibrillation are broadly categorized into "rhythm control" (maintaining sinus rhythm) and …
This multicenter, randomized, placebo controlled trial evaluated the efficacy of prophylactic tranexamic acid in reducing …
Statins are frequently discontinued due to perceived side effects, despite some blinded trials showing no …
The use and meaning of "race" in medicine remain a point of contention among physicians, …
This perspective article examines the implications of restrictive state abortion bans, particularly in light of …
The examination of the neck veins is a standard clinical procedure performed to evaluate right …
This Perspective critiques the evolving jurisprudence of the U.S. Supreme Court and its growing resistance …
A neonate born at 37 weeks of gestation experienced respiratory distress 3 hours after birth, …
Mitral regurgitation arises from anatomical or functional impairment of the mitral apparatus. It is broadly …
This personal perspective by Dr. Bria Peacock, a Black gynecologist, examines the disproportionate impact of …
In 2015, the EMPA-REG OUTCOME trial demonstrated that the sodium-glucose cotransporter 2 (SGLT2) inhibitor empagliflozin …
Immune thrombocytopenia (ITP) is an autoimmune disorder characterized by accelerated platelet destruction and reduced platelet …
One reason to study history is to avoid repeating past mistakes; another is to understand …
This study evaluated the impact of unrestricted mifepristone access on abortion trends in Ontario, Canada, …
This Perspective explores how abortion bans enacted after the Dobbs decision have intensified the risks …
This perspective examines the ethical dilemmas faced by clinicians advocating against abortion bans, focusing on …
This multicenter, noninferiority randomized trial compared single-incision mini-slings (SIMS) with standard midurethral slings (SMUS) in …
This randomized controlled trial (EMPEROR-Reduced) evaluated the efficacy of empagliflozin a sodium-glucose cotransporter 2 (SGLT2) …
This reflective essay explores the evolving culture of psychedelic medicine training and the ethical complexities …
This correspondence reports on the safety and pharmacokinetics of nirsevimab, a monoclonal antibody for preventing …
The Supreme Court’s Dobbs decision has unleashed a wave of state level abortion bans and ignited debates …
This perspective examines the financial and systemic barriers to accessing Opill, the first FDA approved …
This phase 3 trial evaluated the efficacy of adding pembrolizumab to standard chemotherapy (paclitaxel carboplatin) …
This article offers a retrospective and forward-looking analysis of efforts to combat the global obesity …
This article traces the historical and political use of the metaphor of “social contagion” in …
Each year, approximately 350,000 people in the United States experience out-of-hospital cardiac arrest, with only …
This case report describes a premature infant delivered at 32 weeks’ gestation with vesicular skin …
Natural history studies have correlated serotype specific anti-capsular polysaccharide (CPS) IgG in newborns with a …
This study investigated the genetic basis of unexplained female infertility by sequencing the exomes of …
"This clinical review outlines the efficacy, safety, and recommendations for HPV vaccination, which prevents cancers …
This case report details a 72-year-old woman who presented with progressive fatigue and dark urine …
This randomized trial investigated whether immediate treatment of gestational diabetes mellitus (GDM) before 20 weeks' …
This multicenter randomized controlled trial (EAST-AFNET 4) tested whether initiating rhythm-control therapy early in atrial …
This editorial discusses advancements in managing type 1 diabetes during pregnancy, emphasizing the role of …
Background: Respiratory syncytial virus (RSV) is a leading cause of infant mortality globally. This phase …
The U.S. Supreme Court’s Dobbs v. Jackson Women’s Health Organization decision has precipitated a public health crisis …
This multicenter randomized controlled trial (LoDoCo2) investigated the efficacy of low-dose colchicine (0.5 mg once …
In this deeply personal narrative, Dr. Marcia Glass recounts the emotional aftermath of experiencing a …
Primary ovarian insufficiency (POI), affecting ~1% of women under 40, is marked by amenorrhea, elevated …
This editorial discusses the evolving role of cell free DNA (cfDNA) screening in the incidental …
This article explores the essential role of cardiac-resident macrophages (cMacs) in maintaining myocardial homeostasis. Referencing …
This study investigated autism risk in children prenatally exposed to antiseizure medications. A population-based cohort …
A 17 year old girl presented with pruritic genital lesions following unprotected intercourse. Examination revealed …
This randomized controlled trial (DAPA-CKD) evaluated the efficacy of dapagliflozin. a sodium-glucose cotransporter 2 (SGLT2) …
This letter describes the implementation and outcomes of a telemedicine program (Tele-Cardiac Investigations) deployed across …
Background: Homozygous familial hypercholesterolemia (HoFH) is a genetic disorder causing extremely elevated LDL cholesterol levels, …
This study introduces noninvasive prenatal screening using deep trio exome sequencing (DES) to detect fetal genetic abnormalities …
This editorial evaluates why a large implementation-science effort the Healing Communities Study failed to reduce …
In early onset severe hemolytic disease of the fetus and newborn (HDFN), maternal IgG alloantibodies …
This letter presents two cases of symmetric peripheral gangrene (SPG) in critically ill patients with …
This randomized, double-blind, multicenter trial (VERTIS CV) evaluated the long-term cardiovascular and renal safety of …
This article outlines the FDA’s evolving strategy for evaluating the safety of glucose-lowering medications for …
This Perspective article explores the evolving responsibilities and ethical dilemmas faced by physicians serving on …
This interactive feature presents a case-based discussion exploring anticoagulation strategies for a 78-year-old man hospitalized …
This randomized controlled trial (POPular TAVI, cohort A) assessed the impact of single versus dual …
This article calls for treating clinician burnout, impairment, and suicide with the same rigor applied …
This large-scale Norwegian cohort study evaluated changes in self-reported everyday memory problems before and after …
This article critically examines the constructs of burnout and depression as they relate to physician …
This article provides a structured framework for identifying, diagnosing, and treating prolonged grief disorder (PGD) …
This clinical image article presents a case of a 35-year-old woman with a 4-year history …
This study assessed the feasibility, outcomes, and acceptability of a nationwide, couple-based genetic carrier screening …
This case study details the presentation, differential diagnosis, and management of a 30-year-old woman experiencing …
This randomized trial compared three interventions parenteral nutrition, milk supplement, and sensory exposure to milk …
This perspective article explores the legal and ethical implications of a 2024 Alabama Supreme Court …
Highly pathogenic avian influenza A(H5N1) viruses have caused widespread infections in dairy cows and poultry …
This Images in Clinical Medicine report describes a 51-year-old woman who presented with dyspnea and …
This perspective examines the significant disruptions in obstetrics and gynecology residency training following the 2022 …
This comprehensive review traces the global impact of lead poisoning, detailing its historical origins, modern …
This article presents a legal and public health analysis of Brookline, Massachusetts’s pioneering bylaw prohibiting …
This clinical image report describes a 17-year-old girl who presented with deep, painful genital ulcers …
This article introduces the HEROES initiative (Healthcare Rewards to Achieve Improved Outcomes), the first Advanced …
This article examines the ethical tensions and policy challenges posed by clinicians’ conscience-based refusals (CBRs) …
This article outlines clinical strategies for reducing firearm-related injuries and deaths in the U.S., which …
This editorial discusses the compelling and consistent evidence supporting the benefits of sodium-glucose cotransporter 2 …
This article examines the historical role of medical journals, particularly The New England Journal of …
This correspondence reports a case of neonatal stroke caused by transplacentally transferred maternal anti–platelet factor …
This review article explores the growing health risks of endocrine disrupting chemicals (EDCs) that originate …
This article examines how clinicians can help patients with serious illness integrate prognostic information both …
In this reflective perspective piece, Dr. Monique A. Tello recounts a pivotal experience as a …
This narrative describes the four-year journey of a woman with opioid use disorder and a …
This case report details the diagnostic journey of a 16-year-old girl with progressive, intermittent epigastric …
This phase 3, multinational, open-label, noninferiority trial called endTB assessed five all-oral 9-month regimens for …
This article provides a comprehensive clinical framework for assessing and managing sexual dysfunction in women, …
This correspondence details the case of a 32-year-old woman with small-cell carcinoma of the ovary, …
This article analyzes the policy-driven threats to transgender health in the United States under the …
This article explores the lingering psychological and societal effects of the Covid-19 pandemic in the …
This article explores how lactation affects maternal bone loss and recovery. During breastfeeding, calcium demands …
This article examines the legal and public health implications of the Supreme Court case City of …
This perspective explores the political resurgence of pronatalism policies and ideologies that promote childbirth as …
This dual-perspective entry explores structural inequities in healthcare and academia. The first article, authored by …
In a randomized trial involving 3200 pregnant women across Guatemala, India, Peru, and Rwanda, researchers …
This letter to the editor highlights a marked rise in reported exposures of children under …
This Perspective explores the mounting global threat of antifungal drug resistance, underscoring its intertwined impacts …
This correspondence details a severe case of avian influenza A(H5N1) infection in a 13-year-old girl …
This perspective discusses the implications of the Trump administration's temporary suspension of public communications by …
This review outlines current concepts, diagnostic challenges, and evolving therapies for unexplained or refractory chronic …
This article explores the evolving concept of resilience in the context of serious illness and …
This editorial explores evolving insights into postacute sequelae of SARS-CoV-2 infection (PASC), or long Covid, …
This personal narrative explores the psychological, emotional, and symbolic dimensions of organ transplantation through a …
This editorial reflects on a landmark phase 3 trial demonstrating the survival benefit of doxorubicin …
- This phase 3, double-blind, randomized, active-controlled trial (PURPOSE 2) evaluated the efficacy and safety …
This perspective article examines new legal developments in Utah that allow minors who previously consented …
This comprehensive review details the global burden, risk factors, virology, prevention, diagnosis, staging, and treatment …
This comprehensive review outlines best practices for recognizing and managing alcohol use disorder (AUD) across …
This article analyzes the U.S. Supreme Court’s decision to hear FDA v. Wages and White Lion …
This article critically examines how politically motivated restrictions on gender-affirming care particularly for transgender youth …
This study evaluated the cumulative incidence of postacute sequelae of SARS-CoV-2 infection (PASC or “long …
This article provides a comprehensive overview of the assessment and evidence-based management of insomnia disorder, …
This perspective explores Rwanda’s successful containment of a 2024 Marburg virus disease (MVD) outbreak, the …
A 65-year-old man presented with a 1-day history of an itchy rash on his left …
This correspondence presents results from a single-blind, randomized controlled trial evaluating the effectiveness of two …
A 38-year-old woman with a history of disordered eating involving repeated ingestion of salad oil …
This editorial evaluates emerging evidence supporting electronic cigarettes (e-cigarettes) as tools for smoking cessation in …
This multinational cohort study investigated cognitive motor dissociation (CMD)—a condition in which patients with brain …
This article advocates for statutory protections ensuring timely emergency medical care during law enforcement encounters …
This Perspective critiques recent U.S. policy shifts especially under the Trump administration that dismantle foreign aid programs …
This comprehensive review outlines the global burden, pathogenesis, prevention, diagnosis, and treatment of cervical cancer. …
Drawing on over 200 years of archival material, this historical analysis critiques how the New England …
The editorial outlines the shifting landscape of mpox outbreaks in Africa during 2024, emphasizing the …
This diagnostic case study describes a 70-year-old man with a 6-week history of progressive anorexia, …
This article discusses the FDA’s January 2025 proposal to dramatically lower nicotine levels in cigarettes …
In this phase 3, double-blind, placebo-controlled trial (HERCULES), researchers assessed the effect of tolebrutinib a …
This review addresses the public health crisis posed by mass incarceration in the United States, …
- This clinical review discusses the diagnosis and management of acute otitis media (AOM) in …
Resistance to newly endorsed multidrug-resistant tuberculosis (MDR-TB) treatments is already emerging globally. Using whole-genome sequencing …
This perspective article analyzes the legal complexities and challenges surrounding telehealth abortion care provided across …
This large observational study assessed cognitive performance among over 112,000 adults in England who completed …
This Clinical Decisions feature presents a case of expectant parents seeking to transfer their unvaccinated …
In a randomized superiority trial across three Australian hospitals, researchers compared hydrophobic, chlorhexidine-coated, and standard …
This clinical image case describes a 34-year-old woman with HIV infection who developed a blind …
In a randomized, noninferiority trial conducted in Uganda and Kenya, adults received either a standard …
This Perspective calls for a large-scale public health countermarketing campaign to expose and combat the fossil fuel …
This article highlights the sudden removal and alteration of key health-related datasets by U.S. federal …
This article examines the U.S. hepatitis C elimination initiative, which faces challenges related to the …
This Perspective expresses grave concern over a federal order issued in January 2025 by the …
This article traces the evolution of U.S. substance use disorder (SUD) policy from punitive models …
This case study presents a 41-year-old man with syncope, joint swelling, and abnormal chest imaging. …
This article discusses how temporary importation of generic medicines from well-regulated international markets can help …
The SAHARA trial investigated the effect of liberal versus restrictive red-cell transfusion strategies in critically …
In this large-scale, multicenter randomized trial across China, 12,821 patients with type 2 diabetes and …
This population-based cohort study assessed the incidence and clinical spectrum of scrub typhus in 37 …
This perspective article discusses the urgent need for gender-affirming surgical care within U.S. carceral settings. …
In light of persistent health inequities exacerbated by the Covid-19 pandemic, the authors advocate for …
This article reviews the Early and Periodic Screening, Diagnostic, and Treatment (EPSDT) benefit under Medicaid, …
This double-blind, phase 2b, randomized, placebo-controlled trial evaluated the efficacy of BCG revaccination in 1836 …
This Case Records of the Massachusetts General Hospital article presents the evaluation of a 70-year-old …
A 46-year-old woman with multiple myeloma, undergoing treatment with immunosuppressive agents, presented with hoarseness and …
This randomized, controlled 13-week trial evaluated the efficacy and safety of automated insulin delivery (AID) …
A 29-year-old man with well-controlled HIV presented with a painful whitish discoloration on his tongue …
This Perspective critiques the Trump administration’s 2025 executive order to withdraw the U.S. from the …
This article presents a clinical problem-solving case of a 57-year-old woman with a history of …
The article highlights how the rise of long-acting HIV antiretroviral medicines offers a pivotal opportunity …
This phase 3, double-blind, randomized controlled trial followed 1032 participants with obesity and prediabetes for …
This commentary outlines a recalibrated framework for U.S. Covid-19 vaccination policy, emphasizing the need for …
A 48-year-old woman presented with facial nerve palsy, ear pain, and vesicular eruptions on the …
This review examines the U.S. carceral system’s impact on health, describing how incarceration shaped by …
In a randomized, controlled trial conducted across influenza seasons in the Southern Hemisphere (2022–2023), researchers …
This editorial commentary examines the BALANCE trial, a landmark randomized study evaluating 7 versus 14 days …
This double-blind, randomized trial evaluated the efficacy of a 6-month levofloxacin regimen versus placebo in …
This comprehensive Review Article explores the global burden, diagnostic complexity, therapeutic strategies, and public health challenges of …
In this open-label, randomized controlled trial, 164 heterosexual couples were enrolled to determine whether treating …
