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This NEJM editorial evaluates the ADVENT trial, which compared pulsed field ablation (PFA) to conventional …
The ORBITA-2 trial, a double-blind, randomized, placebo-controlled study evaluated the effect of PCI versus placebo …
A 29 month old boy presented with seizures and severe hypocalcemia, accompanied by gait abnormalities …
This editorial reviews the development and scientific impact of AlphaFold, the deep learning system created …
Malnutrition in older adults, defined as undernutrition (protein-energy malnutrition), is a prevalent condition with serious …
This case study presents a 61 year old man with undiagnosed pheochromocytoma who underwent elective …
This phase 1–2 trial evaluated the efficacy and safety of selpercatinib, a selective RET kinase …
The COACH trial a stepped-wedge, cluster-randomized study across 10 hospitals in Ontario, tested whether a …
This first-in-human phase 1 trial evaluated NI006, a recombinant human monoclonal antibody designed to selectively …
This editorial discusses the potential of automated insulin delivery (AID) systems for patients with type …
Aldosterone dysregulation contributes to hypertension. Lorundrostat, an aldosterone synthase inhibitor, was evaluated in a multicenter, …
This editorial contextualizes the RENOVATE-COMPLEX-PCI trial, which demonstrated improved outcomes in complex percutaneous coronary …
This study evaluated the long term effects of bariatric surgery on life expectancy in patients …
This multicenter, randomized, open label trial evaluated the efficacy and safety of a closed loop …
This editorial examines the current evidence and challenges surrounding extracorporeal CPR (ECPR) for out-of-hospital cardiac …
The Covid-19 pandemic has highlighted stark racial and ethnic disparities in infection rates, hospitalizations, and …
This NEJM editorial reviews the BeNeDuctus trial findings and challenges the practice of early pharmacologic …
This editorial evaluates 5-year results from the COAPT trial, which randomized 614 patients with heart …
This review explores the pivotal role of circadian rhythms in human physiology and disease, highlighting …
This editorial discusses the challenges in diabetes management, including inadequate glycemic control despite advancements in …
This study investigated the effects of intensive versus standard blood pressure control in patients with …
This international, randomized TRILUMINATE Pivotal trial evaluated transcatheter edge-to-edge repair (TEER) for symptomatic severe tricuspid …
This case report describes a 47 year old man with type 2 diabetes who developed …
A 33 year old woman with celiac disease presented with painless tongue discoloration lasting 3 …
This personal narrative recounts the author's childhood experience of being diagnosed with type 1 diabetes …
This 3-year follow-up of the EARLY-AF randomized trial evaluated whether initial rhythm-control therapy with cryoballoon …
This editorial examines the evolving evidence base for temperature management following out-of-hospital cardiac arrest, focusing …
